67748-61-2

Usage

Uses

Used in Pharmaceutical Industry:
1,3-Benzothiazole-2-carbonyl chloride is used as a synthetic intermediate for the production of benzothiazole-based pharmaceuticals. Its unique chemical properties and reactivity make it suitable for the development of various drug candidates with potential therapeutic applications.
Used in Agricultural Industry:
In the agricultural sector, 1,3-benzothiazole-2-carbonyl chloride is used as a precursor for the synthesis of benzothiazole-based agrochemicals. These derivatives exhibit biocidal properties, making them valuable for the development of pesticides and other crop protection agents.
Used in Organic Synthesis:
1,3-Benzothiazole-2-carbonyl chloride is used as a reactive acyl chloride in various organic synthesis processes. Its ability to participate in amidation and esterification reactions makes it a versatile building block for the creation of complex organic molecules and compounds.
Used in Research and Development:
In research and development settings, 1,3-benzothiazole-2-carbonyl chloride is utilized as a key component in the exploration of new chemical reactions and the synthesis of novel benzothiazole derivatives. Its unique properties and reactivity contribute to the advancement of scientific knowledge and the discovery of new applications in various fields.

InChI:InChI=1/C8H4ClNOS/c9-7(11)8-10-5-3-1-2-4-6(5)12-8/h1-4H

Upstream product

• 3622-04-6 2-carboxybenzothiazole 
• 79-37-8 oxalyl dichloride 
• 137-07-5 2-amino-benzenethiol 
• 37859-42-0 1,3-benzothiazol-2-ylmethanol 
• 32137-76-1 benzothiazole-2-carboxylic acid ethyl ester 

Downstream Products

• 1026367-03-2 (benzothiazole-2-carbonyl)-(2,4-diphenyl-oxazol-5-yl)-carbamic acid tert-butyl ester 
• 1196486-40-4 benzothiazol-2-yl-{4-[4-(4-methanesulfonyl-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidin-1-yl}-methanone 
• 1187843-63-5 N-(2-(4-methoxyphenyl)-4-phenylthiazol-5-yl)benzo[d]thiazole-2-carboxamide 
• 1187843-32-8 C₁₆H₁₃N₃O₂S 
• 1366109-92-3 C₂₃H₁₉BrN₂O₃SSe 
• 1366109-94-5 2-(Benzothiazol-2-ylcarbonylamino)-4-(4-bromophenyl)selenophene-3-carboxylic acid 
• 1366109-85-4 C₂₃H₁₉ClN₂O₃SSe 
• 1366109-87-6 2-(Benzothiazol-2-ylcarbonylamino)-4-(4-chlorophenyl)selenophene-3-carboxylic acid 

Relevant academic research and scientific papers

Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis

Apoptosis signal-regulating kinase 1 (ASK1), a member of the mitogen-activated protein kinase (MAPK) family, is implicated in many human diseases. Here, we describe the structural optimization of hit compound 7 and conduct further structure-activity relationship (SAR) studies that result in the development of compound 19 with a novel indole-2-carboxamide hinge scaffold. Compound 19 displays potent anti-ASK1 kinase activity and stronger inhibitory effect on ASK1 in AP1-HEK293 cells than previously described ASK1 inhibitor GS-4997. Besides improved in vitro activity, compound 19 also exhibits an appropriate in vivo PK profile. In a dextran sulfate sodium (DSS)-induced mouse model of ulcerative colitis (UC), compound 19 shows significant anti-UC efficacy and markedly attenuates DSS-induced body weight loss, colonic shortening, elevation in disease activity index (DAI) and inflammatory cell infiltration in colon tissues. Mechanistically, compound 19 represses the phosphorylation of ASK1-p38/JNK signaling pathways and suppresses the overexpression of inflammatory cytokines. Together, these findings suggest that ASK1 inhibitors can potentially be used as a therapeutic strategy for UC.

Thiazole carboxamide compound and synthesis and application thereof

The invention relates to a novel thiazole carboxamide compound. R1, R2, Z, X1, X2, X3, n and m have meanings defined in right claims. The compound has a main inhibiting effect on alpha-glucosidase inhibitor, and can be used for preventing or treating dise

Novel tetrahydropyrido[1,2-a]isoindolone derivatives (valmerins): Potent cyclin-dependent kinase/glycogen synthase kinase 3 inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts

The development of CDK and GSK3 inhibitors has been regarded as a potential therapeutic approach, and a substantial number of diverse structures have been reported to inhibit CDKs and GSK-3β in recent years. Only a few molecules have gone through or are currently undergoing clinical trials as CDK and GSK inhibitors. In this paper, we prepared valmerins, a new family containing the tetrahydropyrido[1,2-a]isoindone core. The fused heterocycle was prepared with a straightforward synthesis that was functionalized by a (het)arylurea. Twelve valmerins inhibited the CDK5 and GSK3 with an IC50 100 nM. A semiquantitative kinase scoring was realized, and a cellular screening was done. At the end of our study, we investigated the in vivo potency of one valmerin. Mice exhibited good tolerance to our lead, which proved its efficacy and clearly blocked tumor growth. Valmerins appear also as good candidates for further development as anticancer agents.

Preparation of novel antibacterial agents. Replacement of the central aromatic ring with heterocycles

Discovery of novel antibacterial agents is a significant challenge. We have recently reported on our discovery of novel antibacterial agents in which we have rapidly optimized potency utilizing a parallel chemistry approach. These advanced leads suffer from high affinity for human serum albumin (HSA). In an effort to decrease the affinity for HSA we have prepared a series of heterocyclic analogs, which retained antibacterial activity and demonstrated reduced affinity for HSA.

BENZIMIDAZOLE OR INDOLE AMIDES AS INHIBITORS OF PIN1

The invention relates to compounds of the formula (1) and to pharmaceutically acceptable salts and solvates thereof, wherein the variables are defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula (1) and to pharmaceutical compositions for treating such disorders that contain the compounds of formula (1). The invention also relates to methods of preparing the compounds of formula (1).

Discovery, synthesis, and bioactivity of bis(heteroaryl)piperazines. 1. A novel class of non-nucleoside HIV-1 reverse transcriptase inhibitors

A variety of analogues of 1-[4-methoxy-3,5-dimethylbenzyl]-4-[3- (ethylamino)-2-pyridyl]piperazine hydrochloride (U-80493E) were synthesized and evaluated for their inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). Replacement of the substituted aryl moiety with various substituted indoles provided bis(heteroaryl)piperazines (BHAPs) that were 10-100-fold more potent than U-80493E. The pyridyl portion of the lead molecule was found to be very sensitive to modifications. Extensive preclinical evaluations of several of these compounds led to the selection of 1-[(5-methoxyindol-2-yl)carbonyl]-4-[3-(ethylamino)-2- pyridyl]piperazine methanesulfonate (U-87201E, atevirdine mesylate) for clinical evaluation.