6780-43-4

Basic information

• Product Name: Benzenecarboximidothioic acid, N-phenyl-, methyl ester
• CAS NO: 6780-43-4
• Molecular Formula: C14H13NS
• Molecular Weight: 227.33
• Mol File: 6780-43-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzenecarboximidothioic acid, N-phenyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenecarboximidothioic acid, N-phenyl-, methyl ester(6780-43-4)
• EPA Substance Registry System: Benzenecarboximidothioic acid, N-phenyl-, methyl ester(6780-43-4)

Safety Data

• Hazardous Substances Data: 6780-43-4(Hazardous Substances Data)

Upstream product

• 77-78-1 dimethyl sulfate 
• 636-04-4 N-Phenylbenzothioamide 
• 74-88-4 methyl iodide 
• 10181-56-3 2,2,4,4-tetramethylcyclobutane-1,3-dithione 
• 10181-59-6 2,2,4,4-tetramethyl-3-thioxocyclobutanone 
• 2168-78-7 methyl dithiobenzoate 
• 622-37-7 Phenyl azide 
• 1623-99-0 phenyl sodium 
• 103-72-0 phenyl isothiocyanate 
• 71-43-2 benzene 
• 60-29-7 diethyl ether 

Downstream Products

• 114968-02-4 (3S,4S)-3-(3,4-Dimethoxy-phenyl)-4-methylsulfanyl-1,4-diphenyl-azetidin-2-one 
• 136169-36-3 1-(α-anilinobenzylidene)semicarbazide 
• 142913-77-7 3(SR),4(RS),5(RS)-1,4-diphenyl-4-methylthio-3(4')spiro-(2',2'-dimethyl-5'-methoxycarbonyl-1',3'-dioxolane)-2-azetidinone 
• 142913-77-7 3(RS),4(RS),5(RS)-1,4-diphenyl-4-methylthio-3(4')spiro-(2',2'-dimethyl-5'-methoxycarbonyl-1',3'-dioxolane)-2-azetidinone 
• 5438-81-3 3,3-dimethyl-1,4-diphenyl-azetidin-2-one 
• 111905-37-4 (μ-(phenyl)CN(phenyl))(μ-methylthiolate)diiron hexacarbonyl 
• 87834-20-6 C₁₄H₁₄N₄S 
• 68271-54-5 (3R,4R)-3-(3,4-Dimethoxy-phenyl)-1,4-diphenyl-azetidin-2-one 
• 132313-49-6 3,3-dimethyl-4-methylthio-1,4-diphenylazetidin-2-one 

Relevant articles and documents

115. 1,3-Dipole mit Zentralem S-Atom aus der Umsetzung von Aziden mit Thiocarbonyl-Verbindungen: Eine unerwartete MeS-Wanderung im Abfangprodukt eines 'Thiocarbonyl-aminids' mit Dithiobenzoesaeure-methylester

Reaction of PhN3 with O-methyl thiobenzoate (11a) and thioacetate (11c) as well as with the dithio esters 11b, d at 80 deg C yields the corresponding imidates and thioimidates 12 (Scheme 3).The formation of 12 is rationalized by a 1,3-dipolar cycloaddition of the azide and the C=S group followed by successive elimination of N2 and S.In the three-component reaction of 11b, PhN3, and the sterically crowded thioketone 1a, 1,2,4-trithiolane 13a and 1,4,2-dithiazolidine 3a are formed in addition to 12b (Scheme 4).The heterocycles 13 and 3a are trapping products of 1a and 'thiocarbonyl-aminide' 5a and 'thiocarbonyl-amidine' 2a (Ar= Ph), respectively (Scheme 6).These 1,3-dipoles are formed as reactive intermediates.Surprisingly, in the presence of catalytic amounts of acids, the major product is the (methyldithio)cyclobutyl thioimidate of type 14 (Scheme 5), formed by an acid-catalyzed MeS migration in dithiazolidine 17.A reaction mechanism is proposed in Scheme 7.