67805-97-4

Basic information

• Product Name: 5'-thioadenosine
• Synonyms: 5'-thioadenosine;Adenosine, 5'-thio-
• CAS NO: 67805-97-4
• Molecular Formula: C₁₀H₁₃N₅O₃S
• Molecular Weight: 283.31
• Mol File: 67805-97-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 75-77 °C
• Boiling Point: 661.2±65.0 °C(Predicted)
• Appearance: /
• Density: 2.02±0.1 g/cm3(Predicted)
• PKA: 9.74±0.10(Predicted)
• CAS DataBase Reference: 5'-thioadenosine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-thioadenosine(67805-97-4)
• EPA Substance Registry System: 5'-thioadenosine(67805-97-4)

Safety Data

• Hazardous Substances Data: 67805-97-4(Hazardous Substances Data)

Upstream product

• 84365-04-8 5'-acetylthio-5'-deoxy-2',3'-O-isopropylidene adenosine 
• 14031-35-7 S-Adenosyl-L-methionine 
• 362-75-4 2',3'-isopropylidene adenosine 
• 139361-69-6 5'-acetylthio-5'-deoxyadenosine 
• 58-61-7 adenosine 
• 132628-18-3 (2R,3R,4S,5S)-2-(6-Amino-purin-9-yl)-5-[9-(4-methoxy-phenyl)-9H-xanthen-9-ylsulfanylmethyl]-tetrahydro-furan-3,4-diol 
• 892-48-8 5'-deoxy-5'-chloroadenosine 

Downstream Products

• 1186091-85-9 Ditiazofurin disulfide 
• 1186091-86-0 Tiazofurin adenosine disulfide 
• 5256-83-7 Diadenosine disulfide 
• 1186091-92-8 8-Bromoadenosine adenosine disulfide 
• 1186091-93-9 Di(8-bromoadenosine) disulfide 

Relevant articles and documents

Inactivation of S-adenosyl-L-homocysteine hydrolase with novel 5′-thioadenosine derivatives. Antiviral effects

Synthesis of 5′-S-vinyl-5′-thioadenosine 5, 5′-S-ethynyl-5′-thioadenosine 7 and 5′-S-cyano-5′-thioadenosine 9 is described. Incubation of AdoHcy hydrolase with 5, 7 and 9 resulted in time- and concentration-dependent inactivation of the enzyme and partial depletion of its NAD+ content. From these results and characterisation of metabolites released during the inactivation process, hypothetical mechanisms are suggested. The antiviral activity of 5, 7 and 9 was examined. Significant activities were noted with 5 against Vaccinia, Junin and Taccaribe viruses.

Tryptophan Lyase (NosL): A Cornucopia of 5′-Deoxyadenosyl Radical Mediated Transformations

Tryptophan lyase (NosL) is a radical S-adenosyl-l-methionine (SAM) enzyme that catalyzes the formation of 3-methyl-2-indolic acid from l-tryptophan. In this paper, we demonstrate that the 5′-deoxyadenosyl radical is considerably more versatile in its chem

Method for Identifying Inhibitors Using a Homology Model of Polo-Like Kinase 1

The present invention relates to a homology model for PLK, and the use thereof in assays for the identification of small molecule PLK modulators. The invention further relates to PLK modulators identified by said assays, and their use in the treatment of PLK-related disorders such as proliferative disorders.