84365-04-8

Basic information

• Product Name: Adenosine, 2',3'-O-(1-methylethylidene)-5'-thio-, 5'-acetate
• Synonyms: S-(((3aS,4S,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl) ethanethioate;5'-deoxy-5'-acetylthio-2',3'-O-isopropylideneadenosine;5'-acetylthio-2',3'-O-isopropylidene-5'-deoxyadenosine;5'-acetylthio-2',3'-O-isopropylidene-adenosine;5'-acetylthio-5'-deoxy-2',3'-O-isopropylideneadenosine
• CAS NO: 84365-04-8
• Molecular Formula: C15H19N5O4S
• Molecular Weight: 365.413
• Mol File: 84365-04-8.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 591.3±60.0 °C(Predicted)
• Density: 1.69±0.1 g/cm3(Predicted)
• CAS DataBase Reference: Adenosine, 2',3'-O-(1-methylethylidene)-5'-thio-, 5'-acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Adenosine, 2',3'-O-(1-methylethylidene)-5'-thio-, 5'-acetate(84365-04-8)
• EPA Substance Registry System: Adenosine, 2',3'-O-(1-methylethylidene)-5'-thio-, 5'-acetate(84365-04-8)

Safety Data

• Hazardous Substances Data: 84365-04-8(Hazardous Substances Data)

Usage

Uses

2'',?3''-?O-?(1-?Methylethylidene)?-?5''-?thio-?adenosine 5''-?Acetate is an intermediate in synthesizing Decarboxylated S-Adenosylmethionine Sulfate Salt (D222000), a substrate that is involved in the biosynthesis of polyamines including spermidine, spermine, and thermospermine.

Upstream product

• 24514-56-5 9-((3aR,4R,6S,6aS)-6-(chloromethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-amine 
• 58-61-7 adenosine 
• 892-48-8 5'-deoxy-5'-chloroadenosine 
• 192052-69-0 N⁶-benzoyl-2',3'-isopropylidene adenosine 
• 362-75-4 2',3'-isopropylidene adenosine 
• 507-09-5 tiolacetic acid 
• 5605-63-0 ((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl 4-methylbenzenesulfonate 
• 10387-40-3 potassium thioacetate 

Downstream Products

• 1381762-44-2 N-(2-amino-4-(tert-butyl)phenyl)-5-((((3aS,4S,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)thio)pentanamide 
• 79146-35-3 5'-deoxy-5'-(2-phenylethylthio)adenosine 
• 1619235-18-5 5'-deoxy-2',3'-O-isopropylidene-5'-(2-phenylethylthio)adenosine 
• 1394955-87-3 5'-deoxy-5'-[3-(2-phenylacetamido)propylthio]adenosine 
• 1394956-34-3 C₂₂H₂₃F₆N₇O₄S 
• 1394956-33-2 C₂₀H₂₃F₂N₇O₄S 
• 1394956-31-0 C₂₂H₂₉N₇O₄S 
• 1394956-29-6 C₂₂H₂₉N₇O₄S 
• 1394956-27-4 C₂₁H₂₄F₃N₇O₅S 
• 1394956-26-3 C₂₁H₂₄F₃N₇O₄S 
• 1394956-24-1 C₂₀H₂₄IN₇O₄S 
• 1394956-23-0 C₂₀H₂₄BrN₇O₄S 
• 1394956-21-8 C₂₀H₂₄ClN₇O₄S 

Relevant articles and documents

Synthesis, mechanism of action, and antiviral activity of a new series of covalent mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase

A direct method for the preparation of 5′-S-alkynyl-5′-thioadenosine and 5′-S-allenyl-5′thioadenosine has been developed. Treatment of a protected 5′-acetylthio-5′-deoxyadenosine with sodium methoxide and propargyl bromide followed by deprotection gave th

Potent SARS-CoV-2 mRNA Cap Methyltransferase Inhibitors by Bioisosteric Replacement of Methionine in SAM Cosubstrate

Viral mRNA cap methyltransferases (MTases) are emerging targets for the development of broad-spectrum antiviral agents. In this work, we designed potential SARS-CoV-2 MTase Nsp14 and Nsp16 inhibitors by using bioisosteric substitution of the sulfonium and amino acid substructures of the cosubstrate S-adenosylmethionine (SAM), which serves as the methyl donor in the enzymatic reaction. The synthetically accessible target structures were prioritized using molecular docking. Testing of the inhibitory activity of the synthesized compounds showed nanomolar to submicromolar IC50 values for five compounds. To evaluate selectivity, enzymatic inhibition of the human glycine N-methyltransferase involved in cellular SAM/SAH ratio regulation was also determined, which indicated that the discovered compounds are nonselective inhibitors of the studied MTases with slight selectivity for Nsp16. No cytotoxic effects were observed; however, this is most likely a result of the poor cell permeability of all evaluated compounds.

Sulfonium-Based Homolytic Substitution Observed for the Radical SAM Enzyme HemN

Sulfur-based homolytic substitution (SH reaction) plays an important role in synthetic chemistry, yet whether such a reaction could occur on the positively charged sulfonium compounds remains unknown. In the study of the anaerobic coproporphyrinogen III oxidase HemN, a radical S-adenosyl-l-methionine (SAM) enzyme involved in heme biosynthesis, we observed the production of di-(5′-deoxyadenosyl)methylsulfonium, which supports a deoxyadenosyl (dAdo) radical-mediated SH reaction on the sulfonium center of SAM. The sulfonium-based SH reactions were then investigated in detail by density functional theory calculations and model reactions, which showed that this type of reactions is thermodynamically favorable and kinetically competent. These findings represent the first report of sulfonium-based SH reactions, which could be useful in synthetic chemistry. Our study also demonstrates the remarkable catalytic promiscuity of the radical SAM superfamily enzymes.