678159-98-3Relevant articles and documents
Norrisolide: Total synthesis and related studies
Brady, Thomas P.,Kim, Sun Hee,Wen, Ke,Kim, Charles,Theodorakis, Emmanuel A.
, p. 7175 - 7190 (2007/10/03)
A stereoselective synthesis of (+)-norrisolide is presented. This natural product belongs to a family of marine spongiane diterpenes the structure of which is characterized by a fused γ-lactone-γ-lactol ring system attached to a bicyclic hydrophobic core.
Stereoselective Total Synthesis of (+)-Norrisolide
Brady, Thomas P.,Kim, Sun Hee,Wen, Ke,Theodorakis, Emmanuel A.
, p. 739 - 742 (2007/10/03)
In a convergent approach to the marine natural product (+)-norrisolide (1) the two bicyclic ring systems are coupled through the C9-C10 bond to assemble the carbon framework in a late stage of the synthesis. Other highlights of the synthetic strategy incl