67853-48-9

Upstream product

• 1679-18-1 4-Chlorophenylboronic acid 
• 42432-30-4 p-chlorocinnamyl bromide 
• 13677-54-8 1,3-bis(4-chlorophenyl)prop-2-en-1-ol 
• 1875-88-3 2-(4-Chlorophenyl)ethanol 
• 873-73-4 4-n-chlorophenylacetylene 
• 55-21-0 benzamide 
• 591-87-7 Allyl acetate 
• 79185-37-8 1-(4-chlorophenyl)-3-(4-chlorophenyl)-1-propanol 

Downstream Products

• 101340-93-6 (E)-4,4'-(prop-1-ene-1,3-diyl)dibenzonitrile 
• 110179-65-2 (E)-N,3-bis(4-chlorophenyl)acrylamide 
• 1352732-80-9 (E)-5-(4-chlorostyryl)-1-(4-chlorophenyl)-1H-tetrazole 
• 101385-37-9 1,3-Bis-(4-amidinophenyl)propene 

Relevant academic research and scientific papers

Base-promoted one-pot synthesis of pyridine derivatives via aromatic alkyne annulation using benzamides as nitrogen source

In the presence of Cs2CO3, the first simple, efficient, and one-pot procedure for the synthesis of 3,5-diaryl pyridines via a variety of aromatic terminal alkynes with benzamides as the nitrogen source in sulfolane is described. The formation of pyridine derivatives accompanies the outcome of 1,3-diaryl propenes, which are also useful intermediates in organic synthesis. Thus, pyridine ring results from a formal [2+2+1+1] cyclocondensation of three alkynes with benzamides, and one of the alkynes provides one carbon, whilst benzamides provide a nitrogen source only. A new transformation of alkynes as well as new utility of benzamide are found in this work.

Direct Reduction of Allylic Alcohols Using Isopropanol as Reductant

The lithium cation-catalyzed direct reduction of allylic alcohols to alkenes using isopropanol as a hydride donor was developed. The hydride transfer of the in situ-generated lithium isopropoxide to an allylic cation is the key process in this transformation. The reaction generates only water and acetone as byproducts, which highlights the synthetic utility of this method. (Figure presented.).

Manganese-Catalyzed Dual-Deoxygenative Coupling of Primary Alcohols with 2-Arylethanols

Reported herein is a general and efficient dual-deoxygenative coupling of primary alcohols with 2-arylethanols catalyzed by a well-defined Mn/PNP pincer complex. This reaction is the first example of the catalytic dual-deoxygenation of alcohols using a non-noble-metal catalyst. Both deoxygenative homocoupling of 2-arylethanols (17 examples) and their deoxygenative cross-coupling with other primary alcohols (20 examples) proceeded smoothly to form the corresponding alkenes by a dehydrogenation and deformylation reaction sequence.

Ru-Catalyzed Completely Deoxygenative Coupling of 2-Arylethanols through Base-Induced Net Decarbonylation

Substituted arylethanols can be coupled by using a readily available Ru catalyst in a fully deoxygenative manner to produce hydrocarbon chains in one step. Control experiments indicate that the first deoxygenation occurs through an aldol condensation, whereas the second occurs through a base-induced net decarbonylation. This double deoxygenation enables further development in the use of alcohols as versatile and green alkylating reagents, as well as in other fields, such as deoxygenation and upgrading of overfunctionalized biomass to produce hydrocarbons.

Bi(OTf)3 catalyzed disproportionation reaction of cinnamyl alcohols

Bi(OTf)3 catalyzed disproportionation reaction of cinnamyl alcohols provides chalcones and benzyl styrenes. The use of various metal triflates is investigated herein for facile and efficient redox transformation. A plausible mechanism has been proposed.

Palladium-catalyzed heck-type reactions of allylic esters with arylboronic acids or potassium aryltrifluoroborates

A selective and general route to (E)-1,3-diaryl-prop-1-enes and (E)-3-arylallyl acetates has been developed by palladium-catalyzed Heck-type reactions of allylic esters with arylboronic acids or potassium aryltrifluoroborates. The present method selectively proceeds including β-OAc elimination or β-H elimination on the basis of the boronic acids. Whereas a variety of allylic esters were reacted with arylboronic acids, palladium(II) acetate [Pd(OAc)2], tetra(n-butyl)ammonium chloride [(n-Bu)4NCl] and postassium dihydrogen phosphate (KH 2PO4) to afford the corresponding diarylation products in moderate to good yields, treatment of allylic esters with potassium aryltrifluoroborates furnished the corresponding monoarylation products. Copyright

Preparation of 1,3-Diarylpropenes by Phosphine-Free Palladium(0)-Catalyzed Suzuki-Type Coupling of Allyl Bromides with Arylboronic Acids

1,2-Diarylpropenes 3 featuring different substituents at the aryl rings are obtained in high yields by a modified Suzuki coupling between cinnamyl bromides and arylboronic acids using the phosphine-free Pd(dba)n (n = 1.5-2) as catalyst, in benzene and in

Antiparasitic Agents: Part VII - Synthesis of 1,2-Bis(3,4-substituted phenyl)ethanes and 1,3-Bis(4-amidinophenyl)propene and Their Biological Activity

1,2-Bis(3-substituted 4-amidinophenyl)ethanes (11-13), 1,3-bis(4-amidinophenyl)propene (20), 3,9-dicyano-12,13-dihydrodibenzotriazepine (14) and 1,3-bis(amidinophenyl)propanone (23) have been synthesised.The compounds 11, 12 and 13 when tested for an