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Usage

Uses

Used in Pharmaceutical Industry:
2,2,3,3-Tetrafluoropropyl iodide is used as a reagent and building block for the synthesis of pharmaceuticals, contributing to the development of new drugs with improved properties such as enhanced bioavailability and targeted delivery.
Used in Agrochemical Industry:
In the agrochemical sector, 2,2,3,3-Tetrafluoropropyl iodide is utilized as a precursor in the production of agrochemicals, including pesticides and herbicides, to enhance their effectiveness and selectivity in crop protection.
Used in Industrial Material Production:
2,2,3,3-Tetrafluoropropyl iodide is employed as a key component in the synthesis of materials for various industrial applications, such as high-performance polymers, coatings, and adhesives, due to its unique fluorinated structure and reactivity.
Due to the highly reactive nature and potential health hazards associated with 2,2,3,3-Tetrafluoropropyl iodide, it is crucial to exercise proper safety precautions when handling and using 2,2,3,3-Tetrafluoropropyl iodide in both laboratory and industrial settings.

InChI:InChI=1/C3H3F4I/c4-2(5)3(6,7)1-8/h2H,1H2

Upstream product

• 786-31-2 p-toluenesulfonic acid-2,2,3,3-tetrafluoropropyl ester 
• 2241-68-1 tris(2,2,3,3-tetrafluoropropyl)phosphite 
• 65675-12-9 1,1,3-trihydroperfluoropropyl benzenesulfonate 

Downstream Products

• 40723-63-5 1,1,2,2-Tetrafluorpropan 
• 109230-72-0 4-(2,2,3,3-tetrafluoropropoxy)nitrobenzene 
• 444916-51-2 1-methyl-3-(2,2,3,3-tetrafluoropropoxy)benzene 
• 1132842-92-2 4-methyl-5-[(2,2,3,3-tetrafluoropropylthio)(2,3,6-trifluorophenyl)methyl]pyridine-2-carboxamide 
• 1132842-94-4 4-methyl-5-[(2,3,6-trifluorophenyl)methyl]pyridine-2-carboxamide 
• 133487-66-8 3-(2,2,3,3-tetrafluoropropoxy)benzaldehyde 

Relevant academic research and scientific papers

Highly stereoselective approach to 3-fluoroalkylated (E)-hex-3-ene-1,5- diyne derivatives via an addition-elimination reaction

Palladium(0)-catalyzed Sonogashira cross-coupling reaction of 2-fluoroalkylated (Z)-2-fluoro-1-iodoethene, which is easily prepared from commercially available polyfluorinated alcohols in facile three steps, with terminal alkynes in DMF at room temperature for 24 h took place stereospecifically to give the corresponding 1-fluoroalkylated (Z)-1-fluorobut-1-en-3-yne derivatives in good to excellent yield. Thus obtained fluoroalkylated 1-fluoroenynes were effectively subjected to addition-elimination reaction with various alkynyllithiums at room temperature, leading to 3-fluoroalkylated hex-3-ene-1,5-diyne derivatives in good to high yields with an excellent E selectivity.

Facile syntheses of various per- or polyfluoroalkylated internal acetylene derivatives

Treatment of per- or polyfluoroalkylated vinyl iodides 5 with 2equiv. of n-BuLi in THF produced the corresponding lithium acetylides in situ, which were transformed into zinc acetylides by the addition of ZnCl2· TMEDA complex into the reaction mixture. The in situ generated zinc acetylides were exposed to the cross-coupling conditions such as ArI/cat. Pd(PPh 3)4, reflux, 6-12 h, giving rise to the desired per- or polyfluoroalkylated acetylenes in high yields. In the case of trifluoromethylated acetylene, commercially available 2-bromo-3,3,3-trifluoropropene 6 could also be used instead of 5 as the starting material. In the acetylenes having a fluoroalkyl group and an aliphatic side chain, vinyl iodides 7, prepared by radical addition of perfluoroalkyl iodide to terminal acetylenes, were treated with t-BuOK at room temperature or at the reflux temperature of benzene, affording the desired compounds in good yields.

α,α,ω-TRIHYDRO-α-HALOPERFLUOROALKANES

A synthesis has been developed for α,α,ω-trihydrohaloperfluoroalkanes, H(CF2CF2)n*CH2X, where X is Cl or Br and n is 1 or 4.It is based on the cleavage of the aromatic sulfonate esters of α,α,ω-trihydroperfluoroalkan-α-ols by alkali metal halides.