786-31-2

Basic information

• Product Name: 2,2,3,3-TETRAFLUOROPROPYL 4-TOLUENESULFONATE
• Synonyms: 4-METHYLBENZENESULFONIC ACID 2,2,3,3-TETRAFLUOROPROPYL ESTER;2,2,3,3-TETRAFLUOROPROPYL 4-TOLUENESULFONATE;2,2,3,3-TETRAFLUOROPROPYL 4-TOLUENESULPHONATE;2,2,3,3-TETRAFLUOROPROPYL P-TOLUENESULFONATE;2,2,3,3-TETRAFLUOROPROPYL TOSYLATE;1-Propanol, 2,2,3,3-tetrafluoro-, 1-(4-methylbenzenesulfonate);2,2,3,3-Tetrafluoropropyl 4-methylbenzenesulfonate;2,2,3,3-TETRAFLUOROPROPYL 4-TOLUENESULFOTE
• CAS NO: 786-31-2
• Molecular Formula: C₁₀H₁₀F₄O₃S
• Molecular Weight: 286.24
• Mol File: 786-31-2.mol
• Article Data: 15

Chemical Properties

• Melting Point: 13-16°C
• Boiling Point: 134 °C
• Flash Point: >110°C
• Appearance: /
• Density: 1,4 g/cm3
• Vapor Pressure: 0.000162mmHg at 25°C
• Refractive Index: 1.4602
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2,2,3,3-TETRAFLUOROPROPYL 4-TOLUENESULFONATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,3,3-TETRAFLUOROPROPYL 4-TOLUENESULFONATE(786-31-2)
• EPA Substance Registry System: 2,2,3,3-TETRAFLUOROPROPYL 4-TOLUENESULFONATE(786-31-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 786-31-2(Hazardous Substances Data)

Usage

General Description

2,2,3,3-Tetrafluoropropyl 4-toluenesulfonate is a chemical compound with the formula C9H15F4O3S. It is a fluorinated derivative of toluenesulfonate, which is commonly used as a protecting group in organic synthesis. The compound is a colorless liquid with a molecular weight of 294.28 g/mol. It is commonly used as a reagent in organic synthesis, particularly in the formation of carbon-carbon and carbon-heteroatom bonds. The compound is also utilized as a coupling agent in the production of pharmaceuticals, agrochemicals, and functional materials. As a highly reactive and selective reagent, 2,2,3,3-Tetrafluoropropyl 4-toluenesulfonate plays a crucial role in the development of new chemical processes and materials.

InChI:InChI=1/C10H10F4O3S/c1-7-2-4-8(5-3-7)18(15,16)17-6-10(13,14)9(11)12/h2-5,9H,6H2,1H3

Upstream product

• 41578-54-5 sodium 2,2,3,3-tetrafluoropropan-1-olate 
• 98-59-9 p-toluenesulfonyl chloride 
• 76-37-9 2,2,3,3-tetrafluoropropanol 
• 1153-45-3 4-nitrophenyl 4-methylbenzenesulfonate 

Downstream Products

• 164021-52-7 Toluene-4-sulfonic acid (Z)-2,3,3-trifluoro-1-methyl-propenyl ester 
• 60598-17-6 1,1,2,2-tetrafluoro-3-methoxypropane 
• 444916-51-2 1-methyl-3-(2,2,3,3-tetrafluoropropoxy)benzene 
• 133487-66-8 3-(2,2,3,3-tetrafluoropropoxy)benzaldehyde 
• 103962-17-0 4-(2,2,3,3-tetrafluoropropoxy)-benzaldehyde 
• 205521-85-3 benzyl 2,2,3,3-tetrafluoropropyl sulfide 
• 663-69-4 1H,1H,3H-Tetrafluorpropylamin 
• 679-87-8 1-iodo-1,1,3-trihydroperfluoropropane 
• 679-84-5 1-bromo-2,2,3,3-tetrafluoropropnae 

Relevant articles and documents

Method for preparing hydrofluoroether through two-step process

The invention discloses a method for preparing hydrofluoroether through a two-step process. With the method provided by the invention, p-toluensulfonyl chloride and fluorine-containing alcohol are subjected to a reaction to obtain p-toluenesulfonate, and the p-toluenesulfonate and sodium alkoxide are subjected to a Williamson ether synthetic reaction to obtain the hydrofluoroether. The method disclosed by the invention has the advantages of cheap and low-toxicity raw materials, mild and controllable reaction conditions, and high yield.

Anti-artz sea silent sickness drug Lu - AE - 58054 preparation method (by machine translation)

The invention discloses a novel method for preparing a medicine Lu-AE-58054 for resisting an alzheimer's disease. The novel method comprises the following steps: firstly, reacting 2,2,3,3-tetrafluoromethane-1-propyl alcohol with paratoluensulfonyl chlorid

PROCESS FOR THE MANUFACTURE OF IDALOPIRDINE

Disclosed herein is a process for the preparation of idalopirdine and pharmaceutically acceptable salts thereof.