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cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

67914-86-7

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Basic information
1. Product Name: cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate
2. Synonyms: 2,4-dihydro-4-[[4-(4-hydroxyphenyl)-1-piperazinyl]-phenyl]-2-(1-methylpropyl)-3h-1,2,4-triazole-3-one;Cis-trimesylate;1-[[(2r,4s)-2-(2,4-dichlorophenyl)-4-(methylsulfonyloxymethyl)-1,3-dioxolan-2-yl]methyl]-1,2,4-triazole;1,3-DIOXOLANE-4-METHANOL, 2-(2,4-DICHLOROPHENYL)-2-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-METHANESULFONATE(ESTER),(2R,4R)-REL-;CIS-[2-(2,4-DICHLOROPHENYL)-2-(1,2,4-TRIAZOL-1-YL-METHYL)-1,3-DIOXOLAN-4-YL]METHYL METHANESULPHONATE;CIS-[2-(2,4-DICHLOROPHENYL)-2-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL] METHYL METHANESULFATE;CIS-[2-(2,4-DICHLOROPHENYL)-2-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHYL METHANESULFONATE;cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate
3. CAS NO:67914-86-7
4. Molecular Formula: C₁₄H₁₅Cl₂N₃O₅S
5. Molecular Weight: 408.26
6. EINECS: 267-749-5
7. Product Categories: Pharmaceutical Intermediates;INTERMEDIATESOFITRACONAZOLE;Intermediates & Fine Chemicals;Pharmaceuticals
8. Mol File: 67914-86-7.mol
Chemical Properties
1. Melting Point: 98 °C
2. Boiling Point: 615.5 °C at 760 mmHg
3. Flash Point: 326 °C
4. Appearance: white-to-off-white powder
5. Density: 1.59 g/cm³
6. Vapor Pressure: 4.42E-15mmHg at 25°C
7. Refractive Index: 1.647
8. Storage Temp.: 2-8°C
9. Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
10. PKA: 2.94±0.12(Predicted)
11. CAS DataBase Reference: cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate(CAS DataBase Reference)
12. NIST Chemistry Reference: cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate(67914-86-7)
13. EPA Substance Registry System: cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate(67914-86-7)
Safety Data
1. Hazard Codes: N/A
2. Statements: N/A
3. Safety Statements: N/A
4. WGK Germany:
5. RTECS:
6. HazardClass: N/A
7. PackingGroup: N/A
8. Hazardous Substances Data: 67914-86-7(Hazardous Substances Data)

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67914-86-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 67914-86-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,9,1 and 4 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 67914-86:
(7*6)+(6*7)+(5*9)+(4*1)+(3*4)+(2*8)+(1*6)=167
167 % 10 = 7
So 67914-86-7 is a valid CAS Registry Number.

InChI:InChI=1/C14H15Cl2N3O5S/c1-25(20,21)23-6-11-5-22-14(24-11,7-19-9-17-8-18-19)12-3-2-10(15)4-13(12)16/h2-4,8-9,11H,5-7H2,1H3

67914-86-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name	cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate

1.2 Other means of identification

Product number	-
Other names	Cis-trimesylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:67914-86-7 SDS

67914-86-7Synthetic route

: 124-63-0
methanesulfonyl chloride

: 67914-85-6
cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol

: 67914-86-7
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

Conditions

Conditions	Yield
With pyridine	87%

: 61397-56-6
(+/-)-cis-[2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane-4-yl]methyl benzoate

: 67914-86-7
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) NaH, 3.) aq. NaOH 2: 87 percent / pyridine View Scheme

: 79538-92-4
4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1-methyl-1H-1,2,4-triazol-5(4H)-one

: 67914-86-7
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

: 89848-43-1
4-[4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2-methyl-2,4-dihydro-[1,2,4]triazol-3-one

Conditions

Conditions	Yield
With sodium hydride 1.) Me2SO, 50 deg C, 1 h, 2.) Me2SO, 100 deg C, 3 h; Yield given. Multistep reaction;

: 74853-20-6
1-ethyl-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one

: 67914-86-7
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

: 89848-45-3
4-[4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2-ethyl-2,4-dihydro-[1,2,4]triazol-3-one

Conditions

Conditions	Yield
With sodium hydride 1.) Me2SO, 50 deg C, 1 h, 2.) Me2SO, 100 deg C, 3 h; Yield given. Multistep reaction;

: 79538-91-3
4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-2-propyl-2,4-dihydro-3H-1,2,4-triazol-3-one

: 67914-86-7
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

: 89848-47-5
4-[4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2-propyl-2,4-dihydro-[1,2,4]triazol-3-one

Conditions

Conditions	Yield
With sodium hydride 1.) Me2SO, 50 deg C, 1 h, 2.) Me2SO, 100 deg C, 3 h; Yield given. Multistep reaction;

: 89848-19-1
4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1-isopropyl-1H-1,2,4-triazol-5(4H)-one

: 67914-86-7
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

: 89848-49-7
cis-4-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>-2,4-dihydro-2-(1-methylethyl)-3H-1,2,4-triazol-3-one

Conditions

Conditions	Yield
With sodium hydride 1.) Me2SO, 50 deg C, 1 h, 2.) Me2SO, 100 deg C, 3 h; Yield given. Multistep reaction;

: 74853-17-1
4-{4-[4-(4-Hydroxy-phenyl)-piperazin-1-yl]-phenyl}-2,5-dimethyl-2,4-dihydro-[1,2,4]triazol-3-one

: 67914-86-7
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

: 89848-44-2
4-[4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2,5-dimethyl-2,4-dihydro-[1,2,4]triazol-3-one

Conditions

Conditions	Yield
With sodium hydride 1.) Me2SO, 50 deg C, 1 h, 2.) Me2SO, 100 deg C, 3 h; Yield given. Multistep reaction;

: 89848-21-5
4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1-isobutyl-1H-1,2,4-triazol-5(4H)-one

: 67914-86-7
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

: 89848-53-3
4-[4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2-isobutyl-2,4-dihydro-[1,2,4]triazol-3-one

Conditions

Conditions	Yield
With sodium hydride 1.) Me2SO, 50 deg C, 1 h, 2.) Me2SO, 100 deg C, 3 h; Yield given. Multistep reaction;

: 89848-20-4
1-butyl-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one

: 67914-86-7
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

: 89848-51-1
2-Butyl-4-[4-(4-{4-[(2R,4S)-2-(2,4-dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2,4-dihydro-[1,2,4]triazol-3-one

Conditions

Conditions	Yield
With sodium hydride 1.) Me2SO, 50 deg C, 1 h, 2.) Me2SO, 100 deg C, 3 h; Yield given. Multistep reaction;

: 74853-18-2
2-Ethyl-4-{4-[4-(4-hydroxy-phenyl)-piperazin-1-yl]-phenyl}-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

: 67914-86-7
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

: 89848-46-4
4-[4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2-ethyl-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

Conditions

Conditions	Yield
With sodium hydride 1.) Me2SO, 50 deg C, 1 h, 2.) Me2SO, 100 deg C, 3 h; Yield given. Multistep reaction;

: 89848-22-6
4-{4-[4-(4-Hydroxy-phenyl)-piperazin-1-yl]-phenyl}-2-isopropyl-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

: 67914-86-7
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

: 89848-50-0
4-[4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2-isopropyl-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

Conditions

Conditions	Yield
With sodium hydride 1.) Me2SO, 50 deg C, 1 h, 2.) Me2SO, 100 deg C, 3 h; Yield given. Multistep reaction;

: 74853-19-3
4-{4-[4-(4-Hydroxy-phenyl)-piperazin-1-yl]-phenyl}-5-methyl-2-propyl-2,4-dihydro-[1,2,4]triazol-3-one

: 67914-86-7
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

: 89848-48-6
4-[4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-methyl-2-propyl-2,4-dihydro-[1,2,4]triazol-3-one

Conditions

Conditions	Yield
With sodium hydride 1.) Me2SO, 50 deg C, 1 h, 2.) Me2SO, 100 deg C, 3 h; Yield given. Multistep reaction;

: 89848-24-8
4-{4-[4-(4-Hydroxy-phenyl)-piperazin-1-yl]-phenyl}-2-isobutyl-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

: 67914-86-7
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

: 89848-52-2
4-[4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2-isobutyl-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

Conditions

Conditions	Yield
With sodium hydride 1.) Me2SO, 50 deg C, 1 h, 2.) Me2SO, 100 deg C, 3 h; Yield given. Multistep reaction;

: 67914-86-7
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

: 67914-97-0
4-(4-hydroxyphenyl)-1-(1-methylethyl)piperazine

: 67915-31-5
(+/-)-Terconazole

Conditions

Conditions	Yield
With sodium hydride 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 4 h; Yield given. Multistep reaction;

: 67914-86-7
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

: 67914-60-7, 89929-31-7
N-acetyl-N'-(4-hydroxyphenyl)piperazine

: 67915-35-9
cis-1-acetyl-4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>-methoxy>phenyl>piperazine

Conditions

Conditions	Yield
With sodium hydride 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 5 h; Yield given. Multistep reaction;

: 67914-86-7
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

: 2-sec-Butyl-4-{4-[4-(6-hydroxy-benzo[b]thiophen-3-yl)-piperazin-1-yl]-phenyl}-2,4-dihydro-[1,2,4]triazol-3-one

: 2-sec-Butyl-4-[4-(4-{6-[(2R,4S)-2-(2,4-dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-benzo[b]thiophen-3-yl}-piperazin-1-yl)-phenyl]-2,4-dihydro-[1,2,4]triazol-3-one

Conditions

Conditions	Yield
With sodium hydride 1.) DMSO, 30 min, 2.) DMSO, from 60 deg C to 70 deg C, 2 h; Yield given. Multistep reaction;

: 67914-86-7
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

: 67915-50-8
cis-1-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>piperazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) NaH / 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 5 h 2: 70 percent / NaOH / butan-1-ol / Heating View Scheme

: 67914-86-7
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

: 89848-09-9
cis-1-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>benzenamine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 1.) NaH / 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 5 h 2: 70 percent / NaOH / butan-1-ol / Heating 3: 50 percent / K2CO3 / dimethylsulfoxide / 120 °C 4: 80 percent / H2, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating View Scheme

: 67914-86-7
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

: 89872-79-7
cis-1-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-4-(4-nitrophenyl)piperazine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 1.) NaH / 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 5 h 2: 70 percent / NaOH / butan-1-ol / Heating 3: 50 percent / K2CO3 / dimethylsulfoxide / 120 °C View Scheme

: 67914-86-7
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

: 89848-13-5
cis-1-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>hydrazinecarboxamide

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 1.) NaH / 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 5 h 2: 70 percent / NaOH / butan-1-ol / Heating 3: 50 percent / K2CO3 / dimethylsulfoxide / 120 °C 4: 80 percent / H2, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating 5: 86 percent / pyridine / CHCl3 / 3 h 6: 99 percent / hydrazine hydrate / dioxane / 3 h / Heating View Scheme

: 67914-86-7
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

: 89848-42-0
4-[4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: 1.) NaH / 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 5 h 2: 70 percent / NaOH / butan-1-ol / Heating 3: 50 percent / K2CO3 / dimethylsulfoxide / 120 °C 4: 80 percent / H2, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating 5: 86 percent / pyridine / CHCl3 / 3 h 6: 99 percent / hydrazine hydrate / dioxane / 3 h / Heating 7: 38 percent / NaOAc / butan-1-ol View Scheme

Yield

Multi-step reaction with 7 steps
1: 1.) NaH / 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 5 h
2: 70 percent / NaOH / butan-1-ol / Heating
3: 50 percent / K2CO3 / dimethylsulfoxide / 120 °C
4: 80 percent / H2, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating
5: 86 percent / pyridine / CHCl3 / 3 h
6: 99 percent / hydrazine hydrate / dioxane / 3 h / Heating
7: 38 percent / NaOAc / butan-1-ol
View Scheme

: 67914-86-7
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

: 89848-11-3
cis-phenyl 1-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>carbamate

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 1.) NaH / 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 5 h 2: 70 percent / NaOH / butan-1-ol / Heating 3: 50 percent / K2CO3 / dimethylsulfoxide / 120 °C 4: 80 percent / H2, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating 5: 86 percent / pyridine / CHCl3 / 3 h View Scheme

: 67914-86-7
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

: 89848-59-9
2-sec-Butyl-4-[4-(4-{4-[(2R,4S)-2-(2,4-dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1: 1.) NaH / 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 5 h 2: 70 percent / NaOH / butan-1-ol / Heating 3: 50 percent / K2CO3 / dimethylsulfoxide / 120 °C 4: 80 percent / H2, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating 5: 86 percent / pyridine / CHCl3 / 3 h 6: 99 percent / hydrazine hydrate / dioxane / 3 h / Heating 7: 38 percent / NaOAc / butan-1-ol 8: 68 percent / KOH / dimethylsulfoxide View Scheme

Yield

Multi-step reaction with 8 steps
1: 1.) NaH / 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 5 h
2: 70 percent / NaOH / butan-1-ol / Heating
3: 50 percent / K2CO3 / dimethylsulfoxide / 120 °C
4: 80 percent / H2, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating
5: 86 percent / pyridine / CHCl3 / 3 h
6: 99 percent / hydrazine hydrate / dioxane / 3 h / Heating
7: 38 percent / NaOAc / butan-1-ol
8: 68 percent / KOH / dimethylsulfoxide
View Scheme

67914-86-7Upstream product

67914-86-7Downstream Products

67914-86-7Relevant academic research and scientific papers

Antimycotic Azoles. 6. Synthesis and Antifungal Properties of Terconazole, a Novel Triazole Ketal

Heeres, J.,Hendrickx, R.,Cutsem, J.Van

, p. 611 - 613 (2007/10/02)

The preparation and antifungal properties of cis-1-methoxy>phenyl>-4-(1-methylethyl)piperazine are reported.Terconazole has a high topical in vivo activity against vaginal candidosis in rats and against dermatophytosis in guinea pigs.

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Antimycotic Azoles. 6. Synthesis and Antifungal Properties of Terconazole, a Novel Triazole Ketal

Heeres, J.,Hendrickx, R.,Cutsem, J.Van

, p. 611 - 613 (2007/10/02)