89848-49-7

Basic information

• Product Name: Isopropyl Itraconazole
• Synonyms: Isopropyl Itraconazole;Isopropyl Analog;Itraconazole EP IMpurity D;Itraconazole iMpurity D;cis-4-[4-[4-[4-[[2-(2,4-cis-4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylethyl)-3H-1,2,4-triazol-3-one;4-(4-(4-(4-(((2S,4R)-2-((1H-1,2,4-triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-isopropyl-1H-1,2,4-triazol-5(4H)-o;Itraconazole Isopropyl Analog
• CAS NO: 89848-49-7
• Molecular Formula: C₃₄H₃₆Cl₂N₈O₄
• Molecular Weight: 73.13684
• Product Categories: Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 89848-49-7.mol

Chemical Properties

• Boiling Point: 844.3±75.0 °C(Predicted)
• Appearance: /
• Density: 1.42±0.1 g/cm3(Predicted)
• PKA: 6.38±0.40(Predicted)
• CAS DataBase Reference: Isopropyl Itraconazole(CAS DataBase Reference)
• NIST Chemistry Reference: Isopropyl Itraconazole(89848-49-7)
• EPA Substance Registry System: Isopropyl Itraconazole(89848-49-7)

Safety Data

• Hazardous Substances Data: 89848-49-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Isopropyl Itraconazole is used as an antimycotic agent for treating fungal infections. Its unique structure may offer enhanced efficacy and selectivity against various fungal pathogens, providing a valuable alternative to existing treatments.
Used in COVID-19 Research:
Isopropyl Itraconazole is used as a research compound for investigating its potential role in the treatment and management of COVID-19. Its antimycotic properties may contribute to understanding the complex interactions between fungal infections and the novel coronavirus, potentially leading to new therapeutic strategies.
Used in Drug Development:
Isopropyl Itraconazole is used as a lead compound in the development of new drugs targeting fungal infections and other related diseases. Its unique chemical structure and potential applications make it an attractive candidate for further research and optimization to improve its pharmacological properties and therapeutic potential.

Upstream product

• 89848-19-1 4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1-isopropyl-1H-1,2,4-triazol-5(4H)-one 
• 67914-86-7 cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate 
• 38212-30-5 4-(4-methoxyphenyl)piperazine 
• 100-00-5 4-chlorobenzonitrile 
• 74852-62-3 4-[4-(4-methoxy-phenyl)-piperazin-1-yl]-phenylamine 
• 74852-61-2 1-(4-methoxyphenyl)-4-(4-nitrophenyl)-piperazine 
• 74853-07-9 2,4-dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl ]-phenyl]-3H-1,2,4-triazol-3-one 
• 74852-89-4 N-{4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl}hydrazinecarboxamide 
• 89848-14-6 1-isopropyl-4-(4-(4-(4-methoxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one 
• 74853-06-8 phenyl (4-(4-(4-methoxyphenyl)piperazin-1-yl)phenyl)carbamate 

Relevant articles and documents

Antimycotic azoles. 7. Synthesis and antifungal properties of a series of novel triazol-3-ones

A series of novel triazol-3-ones has been synthesized, and their in vitro and in vivo antifungal properties are reported. Traconazole. which displays a pronounced oral activity against vaginal candidosis in rats and against microsporosis in guinea pigs, has been selected for clinical evaluation.