679404-78-5Relevant academic research and scientific papers
Synthesis of peptidomimetics based on iminosugar and β-D- glucopyranoside scaffolds and inhibiton of HIV-protease
Chery, Florence,Cronin, Linda,O'Brien, Julie L.,Murphy, Paul V.
, p. 6597 - 6608 (2007/10/03)
Synthetic routes to peptidomimetic compounds derived from saccharide scaffolds are described. The regioselective introduction of pivaloyl groups was achieved from N-benzyloxycarbonyl protected 1-deoxymannojirimycin or via D-fructopyranosides. The results from biological evaluation of the saccharide derivatives as HIV-protease inhibitors are included.
Synthesis of an iminosugar based peptidomimetic analogue
Chery, Florence,Murphy, Paul V.
, p. 2067 - 2069 (2007/10/03)
The synthesis of an 1-deoxymannojirimycin based analogue of a known HIV-protease inhibitor is described. The strategies employed for introduction of the pharmacophore groups onto the azasugar scaffold were based on regioselective reactions of the hydroxyl
