679406-27-0Relevant academic research and scientific papers
Synthesis of photoaffinity probes of tautomycin
Kurono, Masakuni,Shimomura, Aya,Isobe, Minoru
, p. 1773 - 1780 (2007/10/03)
Two types of photoaffinity probe, which possesses a benzophenone or a diazirine photophore on the 2-position of tautomycin, were prepared in order to prove the details of binding site to PP1. These photoaffinity probes were designed on the basis of the structure-activity relationship; thus, the diacid moiety is indispensable. The selective introduction of photolabeling units on the 2-position of tautomycin was achieved through the 2-oxime of tautomycin diacid.
