67970-80-3

Usage

Type

Chemical compound; derivative of pyridinone

Known for

Neurotoxic effects; inducing Parkinson's disease in animal models

Linked to

Development of Parkinson's disease in humans; destruction of dopamine-producing neurons in the brain

Researched for

Understanding mechanisms of Parkinson's disease; developing potential treatments; studying other neurodegenerative disorders, such as Alzheimer's disease.

InChI:InChI=1/C12H11NO/c1-13-8-7-11(9-12(13)14)10-5-3-2-4-6-10/h2-9H,1H3

Upstream product

• 36953-37-4 4-bromo-2(1H)-pyridinone 
• 73583-37-6 2-chloro-4-bromopyridine 
• 214342-63-9 4-bromo-1-methyl-1,2-dihydropyridin-2-one 
• 98-80-6 phenylboronic acid 
• 19006-81-6 4-phenylpyridin-2-one 
• 74-88-4 methyl iodide 
• 939-23-1 p-phenylpyridine 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 127956-32-5 1,2-dihydro-2-benzoyl-cyanomethylidene-1-methyl-pyridine 
• 122842-52-8 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-6,6-d2 
• 176514-84-4 1-methyl-4-phenyl-3,6-dihydro-2-pyridone-6,6-d2 
• 94515-22-7 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridin-2-one 
• 118459-65-7 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-2,2,6,6-d4 
• 173278-81-4 1-methyl-4-phenyl-3,6-dihydro-2-pyridone 
• 176514-83-3 1-methyl-4-phenyl-2-pyridone-6-d1 
• 28289-54-5 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine 
• 939-23-1 p-phenylpyridine 
• 72248-89-6 dimethyl 2-methyl-3-oxo-5-phenyl-2-azabicyclo<2.2.2>octa-5,7-diene-7,8-dicarboxylate 
• 127956-33-6 1,2-dihydro-2-(4-methoxybenzoyl-cyanomethylidene)-1-methyl-pyridine 
• 127956-34-7 1,2-dihydro-2-(4-nitrobenzoyl-cyanomethylidene)-1-methyl-pyridine 
• 128127-14-0 N-phenyl-2-methyl-8-phenyl-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5,6-endo-dicarboximide 

Relevant academic research and scientific papers

Asymmetric Homogeneous Hydrogenation of 2-Pyridones

An asymmetric homogeneous hydrogenation of 2(1H)-pyridones has been developed, using a ruthenium complex bearing two chiral N-heterocyclic carbene (NHC) ligands. To the best of our knowledge, the presented reaction is the first example of a homogeneous asymmetric conversion of 2-pyridones into the corresponding enantioenriched 2-piperidones.

Preparation and Reaction of Pyridones: Steric and Electronic Effects on Cycloadditions with 2(1H)-Pyridones

The reactions of series of substituted 2(1H)-pyridones with dimethyl butynedioate have been studied.Cycloadditions across the 3,6-positions can be observed in certain instances and are particularly favoured where steric buttressing occurs between the substituent groups of the starting pyridones.The pyridone could not be induced to react with simple olefins, either by intermolecular or, via incorporation of alkenyl substituents, by intramolecular processes.From the results it is shown that 2-pyridones can be encouraged to behave as reactive classical dienes in cycloaddition reactions.