679805-32-4

Usage

Heterocyclic compound

fused pyrazole and pyrimidine ring system
A compound that contains a ring structure made up of both carbon and nitrogen atoms, with the pyrazole and pyrimidine rings being fused together.

Chloro-phenyl group

attached to the pyrazole ring
A functional group consisting of a chlorine atom and a phenyl group (a ring structure with 6 carbon atoms) attached to the pyrazole ring of the compound.

Piperidine group

attached to the pyrimidine ring
A basic, nitrogen-containing ring structure (C5H10N) that is attached to the pyrimidine ring of the compound.

Methylthio group

attached to the pyrimidine ring
A functional group consisting of a methyl group (CH3) and a sulfur atom (S) attached to the pyrimidine ring of the compound.

Pharmaceutical applications

potential use in medicine
The compound's unique structure and functional groups make it a promising candidate for further research and development in the field of medicinal chemistry, potentially leading to new pharmaceutical applications.

Medicinal chemistry

field of research and development
The branch of chemistry that focuses on the design, synthesis, and development of new pharmaceuticals, utilizing the properties of compounds like 1H-Pyrazolo[3,4-d]pyrimidine, 1-(2-chloro-2-phenylethyl)-6-(methylthio)-4-(1-piperidinyl)for potential therapeutic applications.

Upstream product

• 110-89-4 piperidine 
• 679805-51-7 4-chloro-1-(2-chloro-2-phenylethyl)-6-(methylthio)-4H-pyrazolo[3,4-d]pyrimidin-4-one 
• 679805-47-1 ethyl 5-{[(benzoylamino)carbonothioyl]amino}-1-(2-hydroxy-2-phenylethyl)-1H-pyrazole-4-carboxylate 
• 679805-49-3 1-(2-hydroxy-2-phenylethyl)-6-(methylthio)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one 
• 679805-48-2 1-(2-hydroxy-2-phenylethyl)-6-thioxo-1,5,6,7-tetrahydro-4H-pyrazolo[3,4-d]pyrimidin-4-one 
• 383911-62-4 5-amino-1-(2-hydroxy-2-phenylethyl)-1H-pyrazole-4-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation

We report here the synthesis of new pyrazolo[3,4-d]pyrimidine derivatives along with their biological properties as inhibitors of isolated Src and cell line proliferation (A431 and 8701-BC cells). Such compounds block the growth of cancer cells by interfe

New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation

New 4-aminopyrazolo[3,4-d]pyrimidines bearing various substituents at the position 1 and 6, were synthesized. The new compounds showed antiproliferative activity toward A431 cells, were found to be inhibitors of Src phosphorylation, and induced apoptotic

Pyrazolo[3,4-d]pyrimidines Endowed with Antiproliferative Activity on Ductal Infiltrating Carcinoma Cells

Novel 1,4,6-trisubstituted pyrazolo[3,4-d]pyrimidines are reported with preliminary in vitro activity data indicating that several of them are potent inhibitors (better than the reference compound) of Src phosphorylation of the breast cancer cells 8701-BC

Synthesis of 1-(2-chloro-2-phenylethyl)-6-methylthio-1H-pyrazolo[3,4-d] pyrimidines 4-amino substituted and their biological evaluation

A new series of 4-amino-6-methylthio-1H-pyrazolo[3,4-d]pyrimidines (2a-m) bearing the 2-chloro-2-phenylethyl chain at the N1 position, has been synthesized. The affinity of these compounds for A1 adenosine receptor (A1AR) was measure

4-SUBSTITUTED DERIVATIVES OF PYRAZOLO[3,4-d]PYRIMIDINE AND PYRROLO[2,3-d]PYRIMIDINE AND USES THEREOF

4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine are described. Compounds are active as antitumoural agents.