679805-52-8

Usage

Chemical class

pyrazolopyrimidine
A heterocyclic aromatic compound consisting of a pyrazole ring fused to a pyrimidine ring.

4-chloro substitution

A chlorine atom attached to the fourth position of the pyrimidine ring, which may influence the compound's reactivity and properties.

1-(2-chloro-2-phenylethyl) side chain

A side chain consisting of a 2-chloro-2-phenylethyl group attached to the first position of the pyrazolopyrimidine core, which may affect the compound's biological activity and pharmacokinetics.

6-(ethylthio) side chain

A side chain consisting of an ethylthio group (an ethyl group attached to a sulfur atom) attached to the sixth position of the pyrazolopyrimidine core, which may influence the compound's solubility and membrane permeability.

Potential biological activity

The compound may exhibit biological activity, making it a candidate for further research in pharmaceuticals and medicine.

Pharmaceutical research applications

The compound could be used in the development of new drugs due to its unique chemical structure and potential biological activity.

Promising candidate for various fields

The chemical structure and properties of the compound make it a valuable candidate for study and potential applications in medicine, pharmacology, and other related fields.

Upstream product

• 679805-47-1 ethyl 5-{[(benzoylamino)carbonothioyl]amino}-1-(2-hydroxy-2-phenylethyl)-1H-pyrazole-4-carboxylate 
• 679805-48-2 1-(2-hydroxy-2-phenylethyl)-6-thioxo-1,5,6,7-tetrahydro-4H-pyrazolo[3,4-d]pyrimidin-4-one 
• 383911-62-4 5-amino-1-(2-hydroxy-2-phenylethyl)-1H-pyrazole-4-carboxylic acid ethyl ester 
• 679805-50-6 1-(2-hydroxy-2-phenylethyl)-6-(ethylthio)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one 

Downstream Products

• 1104076-15-4 C₁₉H₂₄ClN₅S 
• 881889-01-6 1-(2-chloro-2-phenyl-ethyl)-4-(2,6-dimethyl-morpholin-4-yl)-6-ethylsulfanyl-1H-pyrazolo[3,4-d]pyrimidine 
• 679805-39-1 1-(2-chloro-2-phenyl-ethyl)-6-ethylsulfanyl-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidine 

Relevant academic research and scientific papers

Identification of a novel pyrazolo[3,4-d]pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice

New pyrazolo[3,4-d]pyrimidines were synthesized and found to inhibit Src phosphorylation in a cell-free assay. Some of them significantly reduced the growth of human osteogenic sarcoma (SaOS-2) cells. The best compound, in terms of inhibitory properties t

Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation

We report here the synthesis of new pyrazolo[3,4-d]pyrimidine derivatives along with their biological properties as inhibitors of isolated Src and cell line proliferation (A431 and 8701-BC cells). Such compounds block the growth of cancer cells by interfe

Pyrazolo[3,4-d]pyrimidines Endowed with Antiproliferative Activity on Ductal Infiltrating Carcinoma Cells

Novel 1,4,6-trisubstituted pyrazolo[3,4-d]pyrimidines are reported with preliminary in vitro activity data indicating that several of them are potent inhibitors (better than the reference compound) of Src phosphorylation of the breast cancer cells 8701-BC

New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation

New 4-aminopyrazolo[3,4-d]pyrimidines bearing various substituents at the position 1 and 6, were synthesized. The new compounds showed antiproliferative activity toward A431 cells, were found to be inhibitors of Src phosphorylation, and induced apoptotic

4-SUBSTITUTED DERIVATIVES OF PYRAZOLO[3,4-d]PYRIMIDINE AND PYRROLO[2,3-d]PYRIMIDINE AND USES THEREOF

4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine are described. Compounds are active as antitumoural agents.