67985-40-4

Upstream product

• 175137-51-6 α-[bis(methylthio)methylene]-2-chloro-β-oxobenzenepropanenitrile 
• 62-53-3 aniline 
• 67985-36-8 (Z)-2-(2-Chloro-benzoyl)-3-methylsulfanyl-3-phenylamino-acrylonitrile 

Downstream Products

• 943773-95-3 ethyl 3-amino-4-oxo-9-phenyl-4,9-dihydrothieno[2,3-b]quinoline-2-carboxylate 
• 78816-82-7 3-Amino-9-phenyl-1H-pyrazolo<3,4-b>chinolin-4(9H)-on 
• 78816-81-6 2-Amino-3-cyan-1-phenyl-4(1H)-chinolon 
• 78816-83-8 4-Amino-2-methyl-10-phenyl-pyrimido<4,5-b>chinolin-5(10H)-on 

Relevant academic research and scientific papers

Microwave-assisted synthesis of quinolones and 4H-1,4-benzothiazine 1,1-dioxides

A rapid method for the preparation of N-aryl-2-methylthio-4-oxo-1,4- dihydroquinoline-3-carbonitriles (2a-e) and N-aryl-3-methylthio-4H-1,4- benzothiazine-2-carbonitrile 1,1-dioxides (2f-o) is reported. The cyclization is accelerated by microwave irradiat

Synthesis and activity of some quinolone derivatives against Plasmodium falciparum in vitro

Quinolones 7a-i and 8a-i were synthesized and tested in vitro as antimalarial against Plasmodium falciparum in chloroquine resistant strain. The above compounds were inactive at concentrations of 1.0 x 10-4 M except the quinolone 3-amino-9-(2,4-dichlorophenyl)-1H-pyrazolo[3,4-b]-4-quinolone 7h which showed IC50 of 5.06 μM given the most interesting results.