78816-82-7

Upstream product

• 67985-40-4 2-methylsulfanyl-4-oxo-1-phenyl-1,4-dihydro-quinoline-3-carbonitrile 
• 67985-36-8 (Z)-2-(2-Chloro-benzoyl)-3-methylsulfanyl-3-phenylamino-acrylonitrile 
• 175137-51-6 α-[bis(methylthio)methylene]-2-chloro-β-oxobenzenepropanenitrile 
• 62-53-3 aniline 

Relevant academic research and scientific papers

Synthesis and activity of some quinolone derivatives against Plasmodium falciparum in vitro

Quinolones 7a-i and 8a-i were synthesized and tested in vitro as antimalarial against Plasmodium falciparum in chloroquine resistant strain. The above compounds were inactive at concentrations of 1.0 x 10-4 M except the quinolone 3-amino-9-(2,4-dichlorophenyl)-1H-pyrazolo[3,4-b]-4-quinolone 7h which showed IC50 of 5.06 μM given the most interesting results.

Reactions of Substituted 1-Thiochromones and 4(1H)-Quinolones with Nucleophiles

1-Thiochromone 1a and 4(1H)-quinolone 1b react with nucleophiles to substitute the methylthio group.Compounds of type 1 are suitable C3-fragments for the synthesis of novel heterocycles.Hydroxylamine leads to 2-amino-1-thiochromone-3-carboxamid