68-90-6 Usage
Uses
Used in Pharmaceutical Industry:
BENZIODARONE is used as a uricosuric agent for controlling hyperuricemia, particularly in patients who have undergone renal transplantation. By increasing the excretion of uric acid, BENZIODARONE helps to maintain healthy uric acid levels and prevent complications associated with hyperuricemia, such as gout and kidney stones.
Originator
Amplivix,Sigma-Tau
Manufacturing Process
The starting product 2-ethyl-3-benzofuranyl p-hydroxyphenyl ketone
(benzaron) was prepared in 4 steps:
1. First step was a reaction of salicylic aldehyde with chloroacetone to produce
2-acetyl-1-benzofuran.
2. It was reduced by hydrazine hydrate in an alkaline medium by process of
Hyuang-Minlon, J.A.C.S., 1946, 68, 2487 to give 2-ethyl-1-benzofurane.
3. 2-Ethyl-3-(4-methoxybenzoyl)-1-benzofuran was obtained from 2-ethyl-1-
benzofuran and 4-methoxy-benzoylchloride in a presence of tin tetrachloride.
4. It was heated with pyridine hydrochloride at 200°-220°C to give 2-ethyl-3-
benzofuranyl p-hydroxyphenyl ketone (benzaron) as described in N.P.B.Hoi,
C.Beaudet; US Patent No. 3,012,042; Dec. 5, 1961.
Benzaron (1 part) was dissolved in a very slight excess of 3% caustic soda. To
this solution is gradually added a slight excess of iodine dissolved in a 25%
aqueous solution of potassium iodide. The resultant solution is acidified with a
20% solution of sodium bisulphite, centrifuged, washed with water and then
recrystallized in acetic acid to give of 2-ethyl-3-benzofuranyl 4-hydroxy-3,5-
diiodophenyl ketone. MP: 167°C.
Therapeutic Function
Coronary vasodilator, Uricosuric
Safety Profile
A poison bj7
intraperitoneal and intravenous routes.
Moderately toxic by ingestion. A flammable
liquid. When heated to decomposition it
emits toxic vapors of I-.
Check Digit Verification of cas no
The CAS Registry Mumber 68-90-6 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 8 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 68-90:
(4*6)+(3*8)+(2*9)+(1*0)=66
66 % 10 = 6
So 68-90-6 is a valid CAS Registry Number.
InChI:InChI=1/C17H12I2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3
68-90-6Relevant academic research and scientific papers
Compound for treatment or prevention of hyperuricemia or gout
-
, (2017/01/26)
The invention discloses a compound for treatment or prevention of hyperuricemia or gout. The compound is the compound shown as formula (I) or formula (II) or pharmaceutical acceptable salts thereof. The compound or its pharmaceutical acceptable salts can be applied to urate excretion promotion so as to treat or prevent hyperuricemia or gout. (formula (1), formula (II)).
Preparation of 2-alkyl-3-(4-hydroxybenzoyl)benzofuran
-
, (2008/06/13)
The invention relates to new molecular complexes of general formula: STR1 in which R represents a straight- or branched-chain alkyl radical having from 1 to 4 carbon atoms and R1 represents one of the radicals: STR2 These molecular complexes are especially useful for the preparation of 2-alkyl-3-(4-hydroxybenzoyl)benzofurans.
Pharmaceutical compositions and methods of producing coronary vasodilation
-
, (2008/06/13)
Pharmaceutical compositions and methods of producing coronary vasodilation by administering substituted benzofurans, for example 2-n-butyl-3-[4' -(2-hydroxy-3-isopropylamino)propoxybenzoyl] benzofuran.
