3343-80-4

Basic information

• Product Name: 2-ethylbenzofuran-3-yl p-methoxyphenyl ketone
• Synonyms: 2-ethylbenzofuran-3-yl p-methoxyphenyl ketone;3-(4-Methoxybenzoyl)-2-Ethylbenzofuran;2-Ethylbenzofuran-3-yl(4-methoxyphenyl) ketone
• CAS NO: 3343-80-4
• Molecular Formula: C₁₈H₁₆O₃
• Molecular Weight: 280.31784
• EINECS: 222-090-2
• Mol File: 3343-80-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 81 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 450.9°Cat760mmHg
• Flash Point: 226.5°C
• Appearance: /
• Density: 1.161g/cm³
• Vapor Pressure: 2.55E-08mmHg at 25°C
• Refractive Index: 1.598
• CAS DataBase Reference: 2-ethylbenzofuran-3-yl p-methoxyphenyl ketone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ethylbenzofuran-3-yl p-methoxyphenyl ketone(3343-80-4)
• EPA Substance Registry System: 2-ethylbenzofuran-3-yl p-methoxyphenyl ketone(3343-80-4)

Safety Data

• Hazardous Substances Data: 3343-80-4(Hazardous Substances Data)

Usage

Uses

2-Ethylbenzofuran-?3-?yl p-?Methoxyphenyl Ketone is used in the preparation of 2-ethylbenzofuran derivatives which are potential human uric acid transporter 1 (hURAT1) inhibitors.

InChI:InChI=1/C18H16O3/c1-3-15-17(14-6-4-5-7-16(14)21-15)18(19)12-8-10-13(20-2)11-9-12/h4-11H,3H2,1-2H3

Upstream product

• 3131-63-3 2-ethylbenzofuran 
• 100-07-2 4-methoxy-benzoyl chloride 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 100-73-2 acrolein dimer 
• 54103-36-5 1-(4-methoxyphenyl)-1,3-pentanedione 
• 90-02-8 salicylaldehyde 
• 1646-26-0 1-(benzo[b]furan-2-yl)ethanone 
• 100-52-7 benzaldehyde 

Downstream Products

• 1477-19-6 benzarone 
• 68-90-6 benziodarone 
• 51073-13-3 benzbromarone methyl ether 
• 3562-84-3 benzbromarone 
• 27432-39-9 1-(2-methoxyphenyl)butan-2-one 
• 65200-70-6 2-(2-methoxyphenyl)-1-(4-methoxyphenyl)ethan-1-one 

Relevant articles and documents

Preparation method of benzbromarone

The invention belongs to the technical field of organic synthesis, and particularly relates to a preparation method of benzbromarone. According to the method disclosed by the invention, polystyrene-loaded aluminum trichloride is used as a catalyst to carry out Friedel-Crafts acylation reaction, so that the catalytic effect is good, and the catalyst can be recycled, in the demethylation reaction process, aluminum trichloride is adopted to replace common pyridine hydrochloride, so that the reaction temperature can be reduced, and the yield can be increased, in the bromination reaction, sodium sulfide and hydrogen peroxide are adopted to replace bromine, so that the technical problems of strong corrosivity of bromine, great harm to human bodies and environmental pollution are solved, and meanwhile, the yield can be further improved.

Lewis Acid-Catalyzed Synthesis of Benzofurans and 4,5,6,7-Tetrahydrobenzofurans from Acrolein Dimer and 1,3-Dicarbonyl Compounds

2,3-Disubstituted benzofurans were synthesized from acrolein dimer and 1,3-dicarbonyl compounds by using N-bromosuccinimide as an oxidizing agent. The method was used to synthesize two commercial drug molecules, benzbromarone and amiodarone. The proposed mechanism of the reaction involves a N-bromosuccinimide (NBS)-assisted autotandem catalysis with Lewis acid catalyst. To proof the proposed mechanism, an intermediate was isolated successfully, which can be converted to 4,5,6,7-tetrahydrobenzofurans.

Compound for treatment or prevention of hyperuricemia or gout

The invention discloses a compound for treatment or prevention of hyperuricemia or gout. The compound is the compound shown as formula (I) or formula (II) or pharmaceutical acceptable salts thereof. The compound or its pharmaceutical acceptable salts can be applied to urate excretion promotion so as to treat or prevent hyperuricemia or gout. (formula (1), formula (II)).