68014-56-2Relevant academic research and scientific papers
Preparation method of hypervalent iodine reagent-mediated chlorobenzene para-amination compound
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Paragraph 0021-0024, (2021/08/14)
The invention relates to a preparation method of a hypervalent iodine reagent mediated chlorobenzene para-amination compound, which comprises the following steps: adding substituted acetanilide, parachloroiodobenzene diethyl ester, chlorobenzene, hexafluoroisopropanol and magneton into a reactor in sequence, putting the reactor into an oil bath pan at 20-40 DEG C, stirring and reacting for 2-6 hours, terminating the reaction, and purifying the product to obtain the chlorobenzene para-amination compound. The method is mild in reaction condition, high in selectivity, relatively high in yield and environment-friendly, and the synthesized chlorobenzene para-aminated compound has relatively good biological activity and can be applied to the fields of drug synthesis, pesticide synthesis, paint dye synthesis and the like.
Transition metal-free N-arylation of secondary amides through iodonium salts as aryne precursors
Wang, Ming,Huang, Zhijian
supporting information, p. 10185 - 10188 (2016/11/11)
By using a diaryliodonium salt as a benzyne precursor, a transition metal-free approach for N-arylation of secondary amides is developed. This novel benzyne precursor, which can be prepared easily by a one step process from an aryl iodide, shows different reactivities with previous benzyne precursors in the N-arylation reaction. Mechanistic studies confirm the involvement of benzyne species (generated in situ from the diaryliodonium salts) as key intermediates.
Aryl halide tolerated electrophilic amination of arylboronic acids with N-chloroamides catalyzed by CuCl at room temperature
He, Chuan,Chen, Chong,Cheng, Jin,Liu, Chao,Liu, Wei,Li, Qiang,Lei, Aiwen
supporting information; experimental part, p. 6414 - 6417 (2009/03/11)
(Chemical Equation Presented) N-Cl is no competition: Aryl halides were tolerated in an efficient ligandless CuCl-catalyzed electrophilic amination reaction of arylboronic acids with N-chloroamides (see scheme; Ac=acetoxy). This coupling proceeded smoothly at ambient temperature, and products were obtained with good to excellent yields.
Oxidative rearrangement of ketimines to amides by MCPBA and BF3·OEt2
Kim, So Yeon,An, Gwang-Il,Rhee, Hakjune
, p. 112 - 114 (2007/10/03)
Several amides were obtained by an efficient method from the corresponding alkyl aryl ketimines in high yields. Ketimines are readily prepared from the corresponding ketones. This procedure involves the oxidation of alkyl aryl ketimines with MCPBA with BF3·OEt2. In this reaction, only aryl group of alkyl aryl ketimines was migrated to the electron deficient nitrogen atom.
