68029-46-9

Usage

Uses

Used in Organic Synthesis:
(2E)-2-cyano-3-(thiophen-2-yl)prop-2-enethioamide is used as a precursor in organic synthesis for the creation of various organic compounds. Its unique structure allows for the modification of its properties to suit specific applications, making it a valuable component in the synthesis of new molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (2E)-2-cyano-3-(thiophen-2-yl)prop-2-enethioamide is utilized for its interesting pharmacological activities. It is considered a potential candidate for drug development due to its ability to be modified and its potential therapeutic properties, contributing to the advancement of new medications.

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 7357-70-2 Cyanothioacetamide 

Downstream Products

• 312757-87-2 (E)-2-[4-(4-Butyl-phenyl)-thiazol-2-yl]-3-thiophen-2-yl-acrylonitrile 
• 277756-72-6 (E)-2-[4-(4-Fluoro-phenyl)-thiazol-2-yl]-3-thiophen-2-yl-acrylonitrile 
• 120517-52-4 4-(2-chlorophenyl)-2-thioxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 277756-79-3 3-thiophen-2-yl-2-(4-p-tolyl-thiazol-2-yl)-acrylonitrile 
• 277756-71-5 (2E)-2-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-3-(thien-2-yl)acrylonitrile 
• 277756-76-0 (E)-2-[4-(4-Methoxy-phenyl)-thiazol-2-yl]-3-thiophen-2-yl-acrylonitrile 
• 59851-02-4 3-cyano-6-phenyl-4-(thiophen-2'-yl)-2(1H)-pyridone 
• 131841-93-5 2-Methylsulfanyl-6-phenyl-4-thiophen-2-yl-nicotinonitrile 
• 136633-81-3 2-Amino-6-(2-oxo-2-phenyl-ethylsulfanyl)-4-thiophen-2-yl-pyridine-3,5-dicarbonitrile 
• 136633-84-6 3,6-Diamino-2-benzoyl-4-thiophen-2-yl-thieno[2,3-b]pyridine-5-carbonitrile 

Relevant academic research and scientific papers

Methods for treating Hepatitis C

In accordance with the present invention, compounds that can inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment or prevention of a viral infection are provided. In another aspect of the invention, compounds useful in the treatment or prevention of HCV infection are provided.

Synthesis and structures of (S)- and (R)-2-[3-cyano-4-(2-thienyl)-5,6,7, 8-tetrahydroquinolin-2-ylsulfanyl]-3-methyl-N-phenylbutyramide

(S)- and (R)-2-[3-cyano-4-(2-thienyl)-5,6,7,8-tetrahydroquinolin-2- ylsulfanyl]-N-phenyl-3-methylbutyramide (1a and 1b) were prepared from 2-thiophenaldehyde and D- and L-valines, respectively, and their crystal structures were elucidated by X-ray crystallography.

Novel heterocyclic compounds having anti-HBV activity

This application relates to novel fused tricyclic thienopyridines of Formulas I and II, which useful for treating Hepatitis B infection and other diseases. This application also relates to pharmaceutical compositions comprising thienopyridines and to the use of such compositions to treat Hepatitis B and other diseases.

Reaction of 3-aryl-2-cyanothioacrylamides with dimethyl acetylenecarboxylate, methyl propiolate, and N-phenylmaleimide

The reaction of cyanothioacrylamides with dimethyl acetylenedicarboxylate, methyl propiolate, and N-phenylmaleimide was studied. The reaction follows a cycloaddition pathway to give thiopyrans, irrespective of the electronic or spatial effects of the substituents in the thioamide group and in position 3 of the 1-thiabuta-1,3-diene system. The reaction is regio-and stereoselective.