127118-65-4

Usage

Structure

Thiopyran ring with functional groups The core structure is a thiopyran ring, which is a six-membered heterocyclic ring containing one sulfur atom.

Amino groups

Two amino groups (-NH2) These groups contribute to the compound's basic properties and can form hydrogen bonds, which are important for its potential applications in medicinal chemistry.

Thiophene ring

Attached at the 2-position of the thiopyran The thiophene ring is a five-membered heterocyclic ring with one sulfur atom, which is attached to the thiopyran ring at the second carbon position.

Cyano groups

Two cyano groups (-CN) These groups are electron-withdrawing and contribute to the compound's stability and potential reactivity in chemical reactions.

Potential applications

Medicinal chemistry The compound can be used as a building block for the synthesis of various biologically active molecules, making it an interesting target for further study and development.

Unique molecular structure

Complex and interesting The combination of the thiopyran ring, amino groups, thiophene ring, and cyano groups results in a unique molecular structure that can be further explored in organic chemistry research.

Upstream product

• 7357-70-2 Cyanothioacetamide 
• 28162-32-5 2-(2-thienyl)-1-cyanoacrylonitrile 
• 98-03-3 thiophene-2-carbaldehyde 
• 107-10-8 propylamine 
• 75-15-0 carbon disulfide 
• 109-77-3 malononitrile 
• 68029-46-9 2-cyano-3-(2-thienyl)-2-propenethioamide 

Downstream Products

• 352325-25-8 4-(4-nitrophenyl)-2-(2-oxo-2H-chromen-3-ylcarbonylmethylsulfanyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile 
• 871799-11-0 3-(4-bromophenyl)-2,2-pentamethylene-11-(2-thienyl)-1,2,3,4,7,8,9,10-octahydropyrimido[4',5':4,5]thieno[2,3-b]quinolin-4-one 
• 369393-46-4 3-amino-N-(4-bromophenyl)-4-(2-thienyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide 
• 277756-76-0 (E)-2-[4-(4-Methoxy-phenyl)-thiazol-2-yl]-3-thiophen-2-yl-acrylonitrile 
• 136633-81-3 2-Amino-6-(2-oxo-2-phenyl-ethylsulfanyl)-4-thiophen-2-yl-pyridine-3,5-dicarbonitrile 
• 136633-84-6 3,6-Diamino-2-benzoyl-4-thiophen-2-yl-thieno[2,3-b]pyridine-5-carbonitrile 

Relevant academic research and scientific papers

CYCLIZATION REACTIONS OF NITRILES

The interaction of 2-thienylidene derivatives of malononitrile and cyanothioacetamide with methylene active nitriles gives 2,6-diamino-3,5-dicyano-4-(2-thienyl)-4H-thiopyran which is smoothly recrystallized into 6-amino-3,5-dicyano-4-(2-thienyl)-2(1H)-pyridinethione.The latter is easily alkylated at the sulfur atom by α-halocarbonyl compounds.This reaction was used in the synthesis of 3,6-diamino-4-(2-thienyl)thienopyridines.

Multicomponent Synthesis of 4-Alkyl(Aryl, Hetaryl)-2-alkoxycarbonyl(aroyl, carbamoyl)- 3,6-diamino-5-cyanothieno[2,3-b]pyridines

The condensation of malononitrile with hydrogen sulfide and aldehydes in the presence of triethylamine in ethanol at room temperature afforded 4-alkyl(aryl, hetaryl)-2,6-diamino-3,5-dicyano-4H-thiopyrans. Treatment of the latter in situ with alkali in DMF, followed by addition of an alkylating agent, led to the formation of 4-alkyl(aryl, hetaryl)-2-alkoxycarbonyl(aroyl, carbamoyl)-3,6-diamino-5-cyanothieno[2,3-b]- pyridines.

Bis(4-pyridylamino)triazine-stabilized magnetite nanoparticles: preparation, characterization and application as a retrievable catalyst for the green synthesis of 4H-pyran, 4H-thiopyran and 1,4-dihydropyridine derivatives

Synthesis of bis(4-pyridylamino)triazine stabilized on silica-coated nano-Fe3O4 particles, and their feasibility as a reusable heterogeneous basic catalyst are reported. The catalytic performance of this novel material was studied fo