68047-36-9

Basic information

• Product Name: 2H-1-Benzopyran-2-one, 6-amino-7-hydroxy-4-methyl-
• Synonyms: 2H-1-Benzopyran-2-one, 6-amino-7-hydroxy-4-methyl-;6-AMino-7-hydroxy-4-MethylcouMarin
• CAS NO: 68047-36-9
• Molecular Formula: C₁₀H₉NO₃
• Molecular Weight: 191
• Product Categories: Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 68047-36-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 431.8 °C at 760 mmHg
• Flash Point: 214.9 °C
• Appearance: /
• Density: 1.407 g/cm³
• Solubility: Methanol
• CAS DataBase Reference: 2H-1-Benzopyran-2-one, 6-amino-7-hydroxy-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1-Benzopyran-2-one, 6-amino-7-hydroxy-4-methyl-(68047-36-9)
• EPA Substance Registry System: 2H-1-Benzopyran-2-one, 6-amino-7-hydroxy-4-methyl-(68047-36-9)

Safety Data

• Hazardous Substances Data: 68047-36-9(Hazardous Substances Data)

Usage

Uses

6-Amino-7-hydroxy-4-methylcoumarin is an aminocoumarin derivatives which shows antiinflammatory activity.

Upstream product

• 91569-85-6 N-(7-hydroxy-4-methyl-2-oxo-2H-chromen-6-yl)acetamide 
• 19037-68-4 7-hydroxy-4-methyl-6-nitro-coumarin 
• 19037-69-5 7-hydroxy-4-methyl-8-nitrocoumarin 
• 13066-95-0 4-aminoresorcinol 
• 141-97-9 ethyl acetoacetate 
• 2735-04-8 2,4-Dimethoxyaniline 
• 1398947-59-5 6-amino-7-(3-hydroxyphenoxy)-4-methyl-2H-chromen-2-one 
• 108-46-3 recorcinol 
• 71516-07-9 N-(2,4-dihydroxyphenyl)-acetamide 
• 23042-75-3 N-(2,4-dimethoxyphenyl)acetamide 
• 90-33-5 7-hydroxy-4-methyl-chromen-2-one 

Downstream Products

• 99422-73-8 6-Hexadecanoylamino-4-methylumbelliferone 

Relevant articles and documents

Novel 4-methylumbelliferone amide derivatives: Synthesis, characterization and pesticidal activities

A series of novel 4-methylumbelliferone amide derivatives were designed, synthesized and characterized by 1H NMR, 13C NMR and HR-ESI-MS. The structures of compounds 4bd and 4be (compounds named by authors) were further confirmed by X-ray single crystal diffraction. The acaricidal, herbicidal and antifungal activities of the synthesized compounds were assayed for their potential use as pesticide. The results indicated that compounds 4bi, 4ac and 4bd were strong acaricidals against Tetranychus cinnabarinus, with 72h corrected mortalities of greater than 80% at 1000 mg/L. Meanwhile, compounds 4bh and 4bf exhibit the strongest inhibition against the taproot development of Digitaria sanguinalis and Chenopodium glaucum, and were even more potent than the commercial herbicide Acetochlor against D. sanguinalis. In addition, compounds 4bk, 4bh and 4bp showed the highest antifungal activity against the mycelium growth of Valsa Mali, which makes them more effective than commercial fungicide Carbendazim.

Understanding the Selectivity of a Multichannel Fluorescent Probe for Peroxynitrite over Hypochlorite

Peroxynitrite is a prominent biological reactive nitrogen species from radical combination of nitric oxide and superoxide and fundamentally involved in broad spectrum physiological and pathological processes. Though redox-inert itself, peroxynitrite anion (OONO-) attacks various biological electrophiles to generate an array of potent 2-e- or 1-e- oxidants, which result in cell injuries. Development of fluorescent probes for peroxynitrite, free from interference from hypochlorite, has been an active endeavor of the chemical community. We previously reported a peroxynitrite probe (PN600), which could differentiate hypochlorite from peroxynitrite through a multichannel signaling mechanism. Herein, this intriguing selectivity was accounted for through a structure-reactivity relationship study. Also, this work, together with rich literature contributions, has allowed a qualitative guideline in the use of electron-rich aromatic moieties to design probes against peroxynitrite and/or hypochlorite. The viability of this guideline was further testified by development of another list of peroxynitrite selective probes.

Oxazole light triggered protecting groups: Synthesis and photolysis of fused heteroaromatic conjugates

Fused oxazole derivatives were synthesized and evaluated as new light triggered protecting groups by using amino acids as model bifunctional molecules. The photosensitivity of ester conjugates was tested under irradiation at 254, 300, and 350 nm. Oxazole