71516-07-9

Upstream product

• 95-21-6 2-methyl-1,3-benzoxazole 
• 546-67-8 lead(IV) tetraacetate 
• 103-90-2 4-acetaminophenol 
• 2735-04-8 2,4-Dimethoxyaniline 
• 71516-10-4 N,O,O-triacetyl-4-aminoresorcinol 

Downstream Products

• 99779-22-3 2-phenyl-6-benzoyloxybenzoxazole 
• 227941-80-2 2-methyl-6-benzoyloxybenzoxazole 
• 227941-79-9 C₂₂H₁₇NO₅ 
• 68047-36-9 6-amino-7-hydroxy-4-methyl-2H-chromen-2-one 

Relevant academic research and scientific papers

Photocatalytic degradation of acetaminophen over Ag, Au and Pt loaded TiO2 using solar light

The sustainability and feasibility of using solar irradiation instead of UV light in photocatalysis is a promising approach for water remediation. In this study, photocatalytic degradation (PCD) of a widely used analgesic and antipyretic drug, acetaminophen (AP), with noble metal loaded TiO2 photocatalysts (Ag/TiO2, Au/TiO2 and Pt/TiO2) was investigated in aqueous suspension using solar light. The deposition of noble metals (Ag, Au and Pt) onto the TiO2 surface enhanced the PCD of AP under different operating conditions including pH, surfactants and drug excipients. However, lower degradation rate constants of AP were obtained under simulated and direct solar light as compared to UV light. The degradation mechanism of AP under UV as well as simulated solar light was found to follow similar, though not identical, reaction pathways leading to hydroxylated intermediates (e.g. 4-acetamidoresorcinol (4-AR), 4-acetamidocatechol (4-AC) and hydroquinone (HQ)) through competitive routes. The PCD of AP followed a pseudo first order kinetics according to Langmiur-Hinshelwood model. Noble metal (Ag, Au and Pt) loaded TiO2 photocatalysts can be used effectively to degrade AP in water under both solar and UV light.

New Facile Synthesis of 7-Hydroxy-6-amino-4-substituted Benzopyran-2-ones

A new facile synthesis of 6-amino-7-hydroxy-4-substituted benzopyranones is described through the von Pechmann reaction. The yields obtained were high, and the proposed methodology leads to pure products. The selectivity of formation of the desired products can be attributed to the formation of an intramolecular hydrogen bond, which leads to reduced reactivity of the 2-hydroxyl group.

The conversion of mixed N,O-diacylated 2-aminophenols to 2-substituted benzoxazoles

When N,O-diacylated 2-aminophenols that have different acyl substituents on nitrogen and oxygen are treated with p-toluenesulfonic acid in refluxing xylenes, mixtures of benzoxazoles are produced. The major product is the benzoxazole in which the substituent at the 2-position is derived from the acyl group on nitrogen. This product may arise from an unusual case of acid- mediated neighboring amido-group assisted hydrolysis.

Oxidations with Lead Tetraacetate. VI. Oxidations of Benzimidazoles, Benzoxazoles and Benzothiazoles

Benzimidazole is slowly oxidized in the imidazole ring by lead tetraacetate to benzimidazol-2(3H)-one, 1-acetylbenzimidazol-2(3H)-one and N,N'-(o-phenylene)bisacetamide.With excess oxidant, oxidation also occurs in the benzene ring at C5.Benzoxazole is much more reactive and gives a variety of products formed by oxidation of both rings.Benzothiazole is the least reactive system and suffers only minimal oxidation at C2 of the thiazole ring.