170011-47-9

Basic information

• Product Name: 1,4-dioxaspiro[4.5]dec-7-en-8-yl trifluoromethanesulfonate
• Synonyms: 1,4-dioxaspiro[4.5]dec-7-en-8-yl trifluoromethanesulfonate
• CAS NO: 170011-47-9
• Molecular Formula: C₉H₁₁F₃O₅S
• Molecular Weight: 288.241
• Mol File: 170011-47-9.mol
• Article Data: 76

Chemical Properties

• Boiling Point: 339.6±42.0 °C(Predicted)
• Appearance: /
• Density: 1.53±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1,4-dioxaspiro[4.5]dec-7-en-8-yl trifluoromethanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-dioxaspiro[4.5]dec-7-en-8-yl trifluoromethanesulfonate(170011-47-9)
• EPA Substance Registry System: 1,4-dioxaspiro[4.5]dec-7-en-8-yl trifluoromethanesulfonate(170011-47-9)

Safety Data

• Hazardous Substances Data: 170011-47-9(Hazardous Substances Data)

Usage

General Description

1,4-dioxaspiro[4.5]dec-7-en-8-yl trifluoromethanesulfonate is a chemical compound with the molecular formula C11H11F3O5S. It is a trifluoromethanesulfonate ester that contains a spirocyclic ring system. 1,4-dioxaspiro[4.5]dec-7-en-8-yl trifluoromethanesulfonate has been used in organic synthesis as a reagent for the preparation of various pharmaceutical and agrochemical compounds. It is known for its ability to facilitate the formation of carbon-carbon and carbon-heteroatom bonds, making it a valuable tool in the pharmaceutical and chemical industries. Additionally, it is considered as a Lewis acid catalyst in various organic reactions.

Upstream product

• 4746-97-8 cyclohexanedione monoethylene ketal 
• 456-64-4 phenyl trifluoromethanesulfonamide 
• 37595-74-7 N,N-phenylbistrifluoromethane-sulfonimide 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 145100-51-2 N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide 
• 145100-50-1 1,1,1-trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methane sulfonamide 

Downstream Products

• 680596-79-6 4,4,5,5-tetramethyl-2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1,3,2-dioxaborolane 
• 155366-02-2 1-(3,5-difluorophenyl)-4-cyclohexenone ethylene ketal 
• 885706-16-1 methyl 4-(1,4-dioxaspiro[4.5]decan-8-yl)benzoate 
• 137464-98-3 4-(4-oxocyclohexyl)benzoic acid methyl ester 
• 176208-16-5 4-(4-carbomethoxyphenyl)cyclohex-3-enone ethylene ketal 

Relevant articles and documents

Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97

Optimization of the side-chain of a phenyl indole scaffold identified from a high-throughput screening campaign for inhibitors of the AAA+ ATPase p97 is reported. The addition of an N-alkyl piperazine led to high potency of this series in a biochemical assay, activity in cell-based assays, and excellent pharmaceutical properties. Molecular modeling based on a subsequently obtained cryo-EM structure of p97 in complex with a phenyl indole was used to rationalize the potency of these allosteric inhibitors.

Discovery of highly potent heme-displacing IDO1 inhibitors based on a spirofused bicyclic scaffold

Through structural modification of an oxalamide derived chemotype, a novel class of highly potent, orally bioavailable IDO1-specific inhibitors was identified. Representative compound 18 inhibited human IDO1 with IC50 values of 3.9 nM and 52 nM in a cellular and human whole blood assay, respectively. In vitro assessment of the ADME properties of 18 demonstrated very high metabolic stability. Pharmacokinetic profiling in mice showed a significantly reduced clearance compared to the oxalamides. In a mouse pharmacodynamic model 18 nearly completely suppressed lipopolysaccharide-induced kynurenine production. Hepatocyte data of 18 suggest the human clearance to be in a similar range to linrodostat (1).

Stereocontrolled synthesis of the cis-hydroxydecalin system: Towards biologically active 19-nor-clerodanes

The 19-nor-clerodanes are compact, densely functionalized diterpenes based on a stereocentre-rich decalin scaffold. To date only a few examples of the 19-nor-clerodanes have been synthesized, hence new flexible strategies are required. We herein describe the stereocontrolled construction of the cis-hydroxy decalin core in a concise fashion.

Total synthesis of the Kopsia lapidilecta alkaloid (±)-lapidilectine B

The total synthesis of Kopsia lapidilecta alkaloid (±)-lapidilectine B is described. Notable elements of this synthesis include the first natural products application of the Smalley azido-enolate cyclization to form the 1,2-dihydro-3H-indol-3-one (indoxyl

3-OXAZOLINONE COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF

The present invention relates to a novel 3-indazolinone compound that regulates or inhibits the activity of indoleamine 2,3-dioxygenase (IDO), the method for the preparation thereof and the use thereof in medicine. In particular, the present invention relates to a compound represented by the general formula (I) and a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the compound or a pharmaceutically acceptable salt thereof, a method for treating or preventing IDO-mediated diseases, especially tumors, by use of the compound or a pharmaceutically acceptable salt thereof, and a method for preparing the compound or a pharmaceutically acceptable salt thereof. The present invention further relates to use of the compound or a pharmaceutically acceptable salt thereof or a composition comprising the compound or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for treating or preventing IDO-mediated diseases, especially tumors.Wherein the substituents of the general formula (I) are defined the same as that in the specification.