68060-36-6Relevant academic research and scientific papers
BRM TARGETING COMPOUNDS AND METHODS OF USE THEREOF
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, (2021/12/31)
The present invention relates to bifunctional compounds comprising a binding fraction to a target protein and a binding fraction to ubiquitin ligase E3, and associated methods of use.
COBALT-MEDIATED ALKYLATION OF SILOXY FURANS
Stuart, John G.,Nicholas, Kenneth M.
, p. 949 - 963 (2007/10/02)
Dicobalt hexacarbonyl complexes of propargylium and α-vinylpropargylium cations couple efficiently with 2-trimethylsiloxyfuran (5), 4-trimethylsilyloxy-2-benzyloxymethylfuran (15) and 2-trimethylsilyl-3-trimethylsilyloxy-4-ethylbenzofuran (20) to produce the corresponding complexed furan derivatives in good yields.A convenient procedure for introducing the 2,4-enyne moiety regio- and stereoselectively into the above heterocycles using this methodology is described.
SILYL NITRONATES AND NITRILE OXIDES IN ORGANIC SYNTHESIS. A NOVEL ROUTE TO D,L-DEOXYSUGARS. USE OF ALUMINIUM OXIDE AS SOLID PHASE BASE FOR GENERATION OF NITRILE OXIDES FROM HYDROXIMIC ACID CHLORIDES
Torssell, K. B. G.,Hazell, A. C.,Hazell, R. G.
, p. 5569 - 5576 (2007/10/02)
Novel methodology is developed for a three step synthesis of deoxyaldoses and deoxyketoses. 1.Regioselective addition of silyl nitronate or nitrile oxide to a diene. 2.Stereospecific hydroxylation of the double bond. 3.Unmasking of the aldol moiety by catalytic reduction of the 2-isoxazoline.The syntheses of D.L-deoxyribose, D,L-oleose, D,L-digitoxose, D,L-2-deoxygalactose, 1,3-dideoxyfructose, 3-deoxyfructose etc. are described.Basic aluminium oxide is introduced as a solid phase base for the one step synthesis of 2-isoxazolines from aldoximes and olefins.An X-ray diffraction study of compound 13c verifies the stereochemical assignments.
