68090-13-1

Upstream product

• 112030-58-7 2-(4-nitrobenzyl)-4,5-dihydro-1H-imidazole 
• 288-32-4 1H-imidazole 
• 122-04-3 4-nitro-benzoyl chloride 
• 51738-10-4 2,2-dibromo-1-(4-nitrophenyl)ethene 

Downstream Products

• 186760-67-8 8-(4-Amino-phenyl)-2,3-dibromo-6H-imidazo[1,2-d][1,2,4]triazin-5-one 
• 1214718-74-7 ethyl 8-(4-nitropheny)imidazo[1,2-a]pyridine-7-carboxylate 
• 1214718-75-8 ethyl 6-methyl-8-(4-nitropheny)imidazo[1,2-a]pyridine-7-carboxylate 
• 1620069-11-5 (S)-4-chloro-N-(4-(1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazole-2-carbonyl)phenyl)benzamide 
• 1620069-12-6 (S)-3-chloro-N-(4-(1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazole-2-carbonyl)phenyl)benzamide 
• 1620069-13-7 C₂₉H₂₈F₃N₇O₄ 
• 1620069-14-8 (S)-N-(4-(1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazole-2-carbonyl)phenyl)-3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)benzamide 
• 1220701-48-3 (S)-4-chloro-N-(4-(1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazole-2-carbonyl)phenyl)-3-(trifluoromethyl)benzamide 
• 1220701-49-4 (S)-1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-(1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazole-2-carbonyl)phenyl)urea 
• 1620069-17-1 (S)-1-(3,4-dichlorophenyl)-3-(4-(1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazole-2-carbonyl)phenyl)urea 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of benzyl 2-(1H-imidazole-1-yl) pyrimidine analogues as selective and potent Raf inhibitors

The synthesis of a novel series of (4-aminobenzyl/benzoyl)-1H-imidazol-1-yl pyrimidin-2-yl derivatives 9, 10, 18, 19 and their in vitro antiproliferative activities against the A375P human melanoma cell line and the U937 human leukemic monocyte lymphoma cell line are described. Potent antiproliferative effects were found from 9l, 9s and 10c; 10c was found to be a highly potent and selective BRAF V600E and CRAF inhibitor (IC50 = 38.3 nM and 8.79 nM).

IMIDAZOLE DERIVATIVES AND COMPOSITIONS FOR TREATING MELANOMA

The present invention relates to novel imidazole derivatives or pharmaceutically acceptable salts thereof, preparation methods thereof and pharmaceutical compositions for prevention and treatment of melanoma containing the same as active ingredients. The

Discovery and initial SAR of pyrimidin-4-yl-1H-imidazole derivatives with antiproliferative activity against melanoma cell lines

The synthesis of a novel series of pyrimidin-4-yl-1H-imidazol-2-yl derivatives 7, 8, 9 and their antiproliferative activities against A375P human melanoma cell line and WM3629 cell line were described. Most compounds showed superior antiproliferative activities compared to Sorafenib, the well-known RAF inhibitor. Among them, 7a exhibited potent activities on both cell lines (IC50 = 0.62 and 4.49 μM, respectively) and turned out to be a selective and potent CRAF inhibitor.

Facile synthesis of imidazo[1,2-a]pyridines via tandem reaction

An efficient method for the synthesis of 5,6,7-trisubstituted imidazo[1,2-a]pyridines was developed. The products were obtained in good yields under mild conditions.

A novel synthetic method for 2-arylmethyl substituted imidazolines and imidazoles from 2-aryl-1,1-dibromoethenes

Various 2-arylmethylimidazolines were prepared by treating readily available 2-aryl-1,1-dibromoethenes with ethylenediamine under mild conditions and further converted into the corresponding imidazoles smoothly with Swern oxidation. Graphical Abstract