68097-01-8Relevant academic research and scientific papers
Rationally derived inhibitors of hepatitis c virus (Hcv) p7 channel activity reveal prospect for bimodal antiviral therapy
Shaw, Joseph,Gosain, Rajendra,Kalita, Monoj Mon,Foster, Toshana L.,Kankanala, Jayakanth,Mahato, D. Ram,Abas, Sonia,King, Barnabas J.,Scott, Claire,Brown, Emma,Bentham, Matthew J.,Wetherill, Laura,Bloy, Abigail,Samson, Adel,Harris, Mark,Mankouri, Jamel,Rowlands, David J.,Macdonald, Andrew,Tarr, Alexander W.,Fischer, Wolfgang B.,Foster, Richard,Griffin, Stephen
, p. 1 - 36 (2020/12/17)
Since the 1960s, a single class of agent has been licensed targeting virus-encoded ion channels, or ‘viroporins’, contrasting the success of channel blocking drugs in other areas of medicine. Although resistance arose to these prototypic adamantane inhibi
A Novel Class of "GABAergic" Agents: 1-Aryl-3-(aminoalkylidene)oxindoles
Sarges, Reinhard,Howard, Harry R.,Koe, B. Kenneth,Weissman, Albert
, p. 437 - 444 (2007/10/02)
Antagonism of mercaptopropionic acid (MPA) induced convulsions, reflecting a GABAergic mechanism, was observed in a series of 1-aryl-3-(aminoalkylidene)oxindoles.Optimal MPA antagonism was associated with 3-halo, 3-alkyl, and/or 4-alkoxy substituents in the pendant aryl ring and with (dimethylamino)methylene, 1-(dimethylamino)ethylidene and N-methyl-2-pyrrolidinylidene side chains.The precise mechanism of action of these agents is unclear at this time; however, they are not GABA mimics and they do not affect GABA levels.Like other GABAergic agents, these compounds are potent enhancers of benzodiazepine binding and they antagonize cyclic GMP elevations induced by isoniazid.Compounds from this series may therefore have potential therapeutic utility as anticonvulsants or anxiolytics.
