68099-99-0Relevant articles and documents
IL-17 Ligands And Uses Thereof
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, (2020/08/20)
Provided herein are novel ligands and pharmaceutical compositions thereof which modulate IL-17A. Also provided are methods for preparing the IL-17A modulators. Such compounds may be useful in the treatment and/or prevention of, for example, inflammation, cancer or autoimmune disease.
An efficient and concise method to synthesize locked GFP chromophore analogues
Chatterjee, Soumit,Karuso, Peter
supporting information, p. 5197 - 5200 (2016/11/13)
A series of GFP analogues, which are fluorescent in the solid state at room temperature, but weakly fluorescent in solution, have been synthesized via an oxazolone formation process that involves a condensation reaction in the presence of a Lewis acid following a Knoevenagel condensation. A ring opened intermediate is formed which cyclizes readily upon heating to produce the imidazolinone. This method is faster, simpler and produces higher yields than alternative methods. A few analogues represent locked GFP derivatives where the exocyclic single bond rotation has been stopped. Weak fluorescence, even after stopping single bond rotation, indicates that restriction of conformation is not effectively controlled and that the double bond rotation is solely responsible for the major non-radiative pathway.
Nanocrystalline titanium dioxide catalyst for the synthesis of azlactones
Anandgaonker, Priyanka,Kulkarni, Ganesh,Gaikwad, Suresh,Rajbhoj, Anjali
, p. 196 - 200 (2014/03/21)
Titanium dioxide nanoparticles were prepared by a electrochemical reduction method using parameters such as current density, solvent polarity, distance between electrodes, and concentration of stabilizers to control the size of the nanoparticles. The nanoparticles were characterized by UV-Vis spectroscopy, X-ray diffraction, scanning electron microscopy and transmission electron microscopy, and their catalytic performance was tested for the synthesis of a series of 4-aryldiene-2-phenyl-5(4)-oxazolones from the cyclodehydration and condensation of the respective aldehyde, hippuric acid and acetic anhydride. Easy availability, reusability and eco-friendliness were some prominent features of the nanocrystalline titanium dioxide catalyst.
Ammonium metavanadate an efficient catalyst for Erlenmeyer synthesis
Madje, Balaji,Ubale, Milind,Bharad, Jagdish,Shingare, Murlidhar
, p. 1295 - 1299 (2013/01/15)
An efficient method to synthesize azalactone derivatives using ammonium metavanadate (NH4VO3) as catalyst was performed in the absence of solvent. This method is environmentally friendly and affords the product azalactones in high yi
A simple and convenient synthesis of 4-ylidene-5(4H)oxazolone derivatives: Oxazolone ring transformation leading to other heterocyclic structures
Abdel-Motaleb, Ramadan M.,Bakeer, Hadeer M.,Tamam, Gammal H.,Arafa, Wael A. A.
, p. 1071 - 1076,6 (2012/12/12)
Simple, effective, and high yield synthetic procedure for the synthesis of 4-ylidene-5(4H)-oxazolones 2a-m from arylidene-malononitriles under solvent-free conditions is described. The scope of this reaction was investigated, and it was found that the presence of anhydrous sodium acetate gave the corresponding oxazolones in excellent yields. The newly generated oxazolone derivative 2m underwent ring transformation into pyrroles, imidazoles, pyridazine, and triazines.
Alum an efficient catalyst for erlenmeyer synthesis
Madje, Balaji R.,Ubale, Milind B.,Bharad, Jagdish V.,Shingare, Murlidhar S.
experimental part, p. 158 - 161 (2012/01/06)
A new and efficient method to synthesize azlactone derivatives using alum ascatalyst was performed in the absence of additional solvent. This method is environmentally friendly and affords the product azlactones in high yields after simple workup.
