681230-42-2Relevant articles and documents
Total synthesis and absolute structure of N55, a positive modulator of GLP-1 signaling
Chein, Rong-Jie,Lin, Nai-Pin
, p. 8899 - 8907 (2020/11/23)
Glucagon-like peptide-1 (GLP-1) signaling is an established therapeutic target for type 2 diabetes mellitus (T2DM). We developed a 7-step synthesis of N55, a positive modulator of GLP-1 signaling isolated from fenugreek (Trigonella foenum-graecum) seeds,
In vitro anti-hyperglycemic activity of 4-hydroxyisoleucine derivatives
Korthikunta, Venkateswarlu,Pandey, Jyotsana,Singh, Rohit,Srivastava, Rohit,Srivastava, Arvind K.,Tamrakar, Akhilesh K.,Tadigoppula, Narender
, p. 66 - 70 (2015/02/05)
The nonproteinogenic amino acid, 4-hydroxyisoleucine (1) has been isolated in large quantities from the fenugreek (T. foenum-graecum) seeds. Few novel derivatives (3-11 and 13-18) were prepared from the naturally occurring 4-hydroxyisoleucine (1) and scre
A Maillard approach to 2-formylpyrroles: Synthesis of magnolamide, lobechine and funebral
Yuen, Tsz-Ying,Eaton, Samantha E.,Woods, Tom M.,Furkert, Daniel P.,Choi, Ka Wai,Brimble, Margaret A.
, p. 1431 - 1437 (2014/03/21)
A convenient synthesis of the traditional medicine constituents magnolamide, lobechine and funebral is described. Construction of the 2-formylpyrrole core of these natural products was achieved by means of a Maillard reaction, involving condensation of the sugar surrogate, dihydropyranone 9, with the requisite primary amines. This approach offers a very direct and general route to the 2-formylpyrrole ring system. The synthesis of the 2-formylpyrrole core found in the traditional medicine constituents, magnolamide, lobechine and funebral, was constructed by a Maillard reaction, involving condensation of the sugar surrogate, dihydropyranone 9, with the requisite primary amines. This approach offers a very direct and general route to the 2-formylpyrrole ring system. Copyright
