717927-37-2

Basic information

• Product Name: (+)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinone
• Synonyms: (+)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinone
• CAS NO: 717927-37-2
• Molecular Weight: 429.362
• Mol File: 717927-37-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: (+)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinone(717927-37-2)
• EPA Substance Registry System: (+)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinone(717927-37-2)

Safety Data

• Hazardous Substances Data: 717927-37-2(Hazardous Substances Data)

Upstream product

• 785-56-8 3,5-bis(trifluoromethyl)phenyl carboxylic acid chloride 
• 681291-90-7 C₂₃H₂₁F₆NO₃ 
• 193201-63-7 (±)-7-(phenylmethyl)-1,4-dioxa-8-azaspiro[4.5]decane 
• 123387-51-9 tert-butyl 1,4-dioxa-8-azaspiro[4.5]decane-8-carboxylate 
• 100-52-7 benzaldehyde 
• 190964-86-4 (+/-)-1-[3,5-bis-(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinone 

Downstream Products

• 681291-91-8 (+)-(2R-trans)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-[4-(phenylmethyl)-1-piperazinyl]piperidine 
• 717923-55-2 C₂₉H₃₄F₆N₄O 
• 717923-65-4 C₃₁H₃₅ClF₆N₄O₂ 
• 717923-54-1 C₃₆H₄₀F₆N₄O 

Relevant articles and documents

Process development of the synthetic route to R116301

We describe in this paper the synthesis of compound 1 (R116301), which was developed to prepare pilot scale quantities (20-50 kg) of drug substance. The synthesis involves the sBuLi deprotonation of Boc-protected piperidone acetal 2, followed b

SUBSTITUTED OXA-DIAZA-SPIRO-[5.5]-UNDECANONE DERIVATIVES AND THEIR USE AS NEUROKININ ANTAGONISTS

This invention concerns substituted oxa-diaza-spiro-[5.5]-undecanone derivatives having neurokinin antagonistic activity, in particular an NK1 antagonistic activity, an NK3 antagonistic activity, a combined NK1/NK2/s

SUBSTITUTED DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES AND THEIR USE AS NEUROKININ ANTAGONISTS

This invention concerns substituted diaza-spiro-[4.5]-decane derivatives having neurokinin antagonistic activity, in particular NK1 antagonistic activity, a combined NK1/NK2 antagonist ic activity, a combined NK1/NK3 antagonist ic activity and a combined NK1/NK2/NK3 antagonistic activity, their preparation, compositions comprising them and their use as a medicine, in particular for the treatment and/or prophylaxis of schizophrenia, emesis, anxiety and depression, irritable bowel syndrome (IBS), circadian rhythm disturbances, pre-eclampsia, nociception, pain, in particular visceral and neuropathic pain, pancreatitis, neurogenic inflammation, asthma, chronic obstructive pulmonary disease (COPD) and micturition disorders such as urinary incontinence. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.