6814-21-7

Upstream product

• 108-94-1 cyclohexanone 
• 67-64-1 acetone 
• 111-87-5 octanol 
• 124-13-0 Octanal 
• 30152-60-4 5',6',7',8'-tetrahydro-1'H-spiro[cyclohexane-1,2'-quinazolin]-4'(3'H)-one 
• 22945-27-3 cyclohexanone-2-carboxamide 
• 286-20-4 cyclohexane-1,2-epoxide 
• 172288-49-2 cyclohexyl cyclohexenylamine 
• 111-66-0 oct-1-ene 
• 6814-23-9 (+/-)-trans-2-Octyl-cyclohexanol 

Downstream Products

• 1619-89-2 6-Oxo-tetradecansaeure 

Relevant academic research and scientific papers

One-pot synthesis of 2-alkyl cycloketones on bifunctional Pd/ZrO2 catalyst

2-Alkyl cycloketones are essential chemicals and intermediates for synthetic perfumes and pesticides, which are conventionally produced by multistep process including aldol condensation, separation and hydrogenation. In present work, a batch one-pot cascade approach using aldehydes and cycloketones as the raw materials, and a bifunctional Pd/ZrO2 catalyst was developed for the synthesis of 2-alkyl cycloketones, e.g., cyclohexanone and cycloheptanone. Very high aldehydes (except for paraldehyde with large steric hindrance) conversion and high yields for 2-alkyl cycloketones (e.g., 99 % of conversion for n-butanal and 76 wt.% of yield for 2-butyl cyclohexanone) were obtained at mild temperature of 140 °C. After 10 cycles of reuse, Pd/ZrO2 catalyst showed slight deactivation (ca. 5 % conversion and 10 % yield losses), due to the coke on the catalyst. However, the performance of the catalyst was completely recovered after an oxidative regeneration.

Clean borrowing hydrogen methodology using hydrotalcite supported copper catalyst

The catalytic activity of Mg-Al hydrotalcite supported copper catalyst was investigated for clean CC and CN bond forming reactions using alcohols as alkylating agent via borrowing hydrogen methodology. The catalyst showed excellent conversion of ketone and amine substrates (71-99%) to alkylated products with high selectivity in alkylation reactions.

Process for the preparation of organic compounds with manganese cataylsts or the like

A process of the present invention produces an organic compound by allowing a compound containing an electron attractive group of following Formula (1): 1wherein Y is an electron attractive group; and Rb and Rc are each a hydrogen atom or an organic group, where Y, Rb and Rc may respectively be combined with each other to form a ring with an adjacent carbon atom, to react with a compound containing an unsaturated carbon-carbon bond of following Formula (2) or 2wherein Rd, Re, Rf, Rg, Ri and Rj are each a hydrogen atom or an organic group, where Rd, Re, Rf and Rg may respectively be combined to form a ring with one or two adjacent carbon atoms, and Ri and Rj may be combined to form a ring with adjacent two carbon atoms, in the presence of oxygen and a catalytic compound of a Group 5, 6, 7, 8 or 9 element of the Periodic Table of Elements to yield a compound of following Formula (3) or (8): 3wherein Z is a hydrogen atom or a hydroxyl group; and Y, Rb, Rc, Rd, Re, Rf, Rg, Ri and Rj have the same meanings as defined above. This process can efficiently produce a compound having an alkyl group or alkenyl group bonded at the alpha position of an electron attractive group, or a derivative thereof, by catalytic radical addition reaction.

PROCESS FOR THE PREPARATION OF ORGANIC COMPOUNDS WITH MANGANESE CATALYSTS OR THE LIKE

A process of the present invention produces an organic compound by allowing a compound containing an electron attractive group of following Formula (1):wherein Y is an electron attractive group; and Rb and Rc are each a hydrogen atom or an organic group, where Y, Rb and Rc may respectively be combined with each other to form a ring with an adjacent carbon atom, to react with a compound containing an unsaturated carbon-carbon bond of following Formula (2) or (7):wherein Rd, Re, Rf, Rg, Ri and Rj are each a hydrogen atom or an organic group, where Rd, Re, Rf and Rg may respectively be combined to form a ring with one or two adjacent carbon atoms, and Ri and Rj may be combined to form a ring with adjacent two carbon atoms, in the presence of oxygen and a catalytic compound of a Group 5, 6, 7, 8 or 9 element of the Periodic Table of Elements to yield a compound of following Formula (3) or (8):wherein Z is a hydrogen atom or a hydroxyl group; and Y, Rb, Rc, Rd, Re, Rf, Rg, Ri and Rj have the same meanings as defined above. This process can efficiently produce a compound having an alkyl group or alkenyl group bonded at the alpha position of an electron attractive group, or a derivative thereof, by catalytic radical addition reaction.

Catalytic radical addition of ketones to alkenes by a metal-dioxygen redox system

Radical addition of ketones to alkenes catalyzed by Mn(OAc)2 combined with Co(OAc)2 using dioxygen as oxidant was developed; for instance, the reaction of cyclohexanone with oct-1-ene in the presence of very small amounts of Mn(OAc)2 and Co(OAc)2 under air (1 atm) gave 2-octylcyclohexanone in good selectivity; from styrene, a six-membered cyclic peroxide was isolated in good yield.

SUBSTITUTED TETRAHYDROBENZOPYRROLYL-FURANOIC ACID DERIVATIVES AS PHOSPHOLIPASE A2 INHIBITORS

Compounds of the formula wherein R is hydrogen, alkyl1-8, geminal alkyl1-3, un-substituted or substituted aryl; X is alkylene, ?CR1=CR2? (E and/or Z), carbonyl, oxygen or sulfur, wherein one of Ri and R2 is alkyli.3 and the other is hydrogen; Y is unsubstituted alkyh-n or substituted by one or more alkyl1-3 groups, or unsubstituted or substituted phenylalkyl 1-3; or a salt thereof with a pharmaceutically acceptable base, are described. The compound of formula I are potent inhibitors of phospholipase A2 (PLA2) and are therefore useful in the treatment of inflammatory diseases, such as, psoriasis, inflammatory bowel disease, asthma, allergy, arthritis, dermatitis, gout, pulmonary, myocardial ischemia and trauma induced inflammation, such as, spinal cord injury

Resolution of Racemic ε-Lactones

Kinetic resolution of racemic ε-lactones by Pig Liver Esterase give optically active R (+) ε-lactones.When alkyl group is higher than propyl, Horse Liver Esterase leads to the destruction of the opposite enantiomer.Enantiomeric excess is easily evaluated by G.C. on a chiral stationary phase.