6814-99-9

Usage

InChI:InChI=1/C5H12N2S/c1-3-4(2)7-5(6)8/h4H,3H2,1-2H3,(H3,6,7,8)

Upstream product

• 116724-11-9 sec-butyl isothiocyanate 
• 89487-47-8 (1-methyl-allyl)-thiourea 
• 14294-20-3 N-(sec-Butyl)-N'-(t-pentyl)-thioharnstoff 
• 7732-18-5 water 
• 25343-21-9 1-Benzoyl-3-sec-butyl-thiourea 
• 2253-71-6 1-methyl-allyl isothiocyanate 
• 2253-92-1 but-2-enylsulfanyl cyanate 
• 513-49-5 (S)-2-aminobutane 
• 532-55-8 Benzoyl isothiocyanate 
• 14327-00-5 N-(sec-butyl)-N'-(tert-butyl)-thiourea 
• 623-45-0 (S)-Butyl-⁽²⁾-isothiocyanat 

Downstream Products

• 96112-87-7 17α-Hydroxy-17β-(2-sec-butylamino-thiazolyl-4-yl)-androst-4-en-3-one 

Relevant academic research and scientific papers

Process for preparing 2-aminothiazole-5-carboxamides useful as kinase inhibitors

The invention is directed to processes for preparing 2-aminothiazole-5-carboxamides of formula I [image] wherein R1, R2, R3, R4 and R5 are as defined as set forth in the specification herein.

A convenient and efficient method for the synthesis of mono- and N,N-disubstituted thioureas

A convenient method for the synthesis of mono- and N,N-disubstituted thioureas by the debenzoylation of N-substituted- and N,N-disubstituted- N′-benzoylthioureas with hydrazine hydrate under solvent-free conditions has been developed. N-Substituted-N′-benzoylthioureas and hydrazine hydrate were mixed, and stirred at room temperature without a solvent to give the corresponding N-substituted thioureas in high yields.

PROCESS FOR PREPARING 2-AMINOTHIAZOLE-5-AROMATIC CARBOXAMIDES AS KINASE INHIBITORS

The invention relates to processes for preparing compounds having the formula (I) and crystalline forms thereof, wherein Ar is aryl or heteroaryl, L is an optional alkylene linker, and R2, R3, R4, and R5, are as defined in the specification herein, which compounds are useful as kinase inhibitors, in particular, inhibitors of protein tyrosine kinase and p38 kinase.

THIAZOLE DERIVATIVES AND USE THEREOF

The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.