68141-13-9

Usage

Uses

Used in Chemical Synthesis:
6-TERT-BUTYLQUINOLINE is used as an intermediate in the synthesis of pharmaceuticals and other organic compounds, contributing to the development of new drugs and chemical products.
Used in Corrosion Inhibition:
6-TERT-BUTYLQUINOLINE is used as a corrosion inhibitor, protecting materials from degradation and extending their service life in various industrial settings.
Used in Rubber and Plastics Production:
6-TERT-BUTYLQUINOLINE is used as a component in the production of rubber, plastics, and other industrial products, enhancing their properties and performance.
Used in Research and Development:
6-TERT-BUTYLQUINOLINE is utilized in research and development laboratories for various applications, including the study of its chemical properties and potential uses in new formulations and processes.
Safety Considerations:
It is important to handle 6-TERT-BUTYLQUINOLINE with caution due to its potential health and environmental hazards, ensuring proper safety measures are in place during its use and disposal.

InChI:InChI=1/C13H15N/c1-13(2,3)11-6-7-12-10(9-11)5-4-8-14-12/h4-9H,1-3H3

Upstream product

• 3282-56-2 4-tert-butylnitrobenzene 
• 769-92-6 4-tert-Butylaniline 
• 127-68-4 sodium 3-nitrobenzenesulfonate 
• 504-63-2 trimethyleneglycol 
• 56-81-5 glycerol 

Downstream Products

• 75413-98-8 6-t-butyl-1,2,3,4-tetrahydroquinoline 
• 75414-04-9 6-tert-butyl-5,6,7,8-tetrahydroquinoline 
• 958328-21-7 6-TERT-BUTYL-N-((1R)-1-{2-FLUORO-5-METHYL-4-[(METHYLSULFONYL)AMINO]PHENYL}-ETHYL)QUINOLINE-2-CARBOXAMIDE 
• 1609198-99-3 6-(tert-butyl)-4-(1-phenylethyl)quinoline 
• 1609199-06-5 C₂₁H₂₃N 
• 958328-02-4 6-tert-butyl-N-((1R)-1-{3-methyl-4[(methylsulfonyl)amino]phenyl}-ethyl)quinoline-2-carboxamide 

Relevant academic research and scientific papers

Mild environment-friendly oxidative debenzylation of N-benzylanilines using DMSO as an oxidant

Oxidative debenzylation of N-benzyl aromatic amines using DMSO as a non-toxic oxidant and catalyzed by TsOH gave Nphenylimines, which were spontaneously hydrolyzed to form anilines and benzaldehydes in good yields. This reaction employs mild, metal-free conditions. The conditions are also suitable for the debenzylation of benzylphenylethers.

Assembly of Diversely Substituted Quinolines via Aerobic Oxidative Aromatization from Simple Alcohols and Anilines

An aerobic oxidative aromatization of simple aliphatic alcohols and anilines under the Pd(OAc)2/2,4,6-Collidine/Br?nsted acid catalytic system has been established, providing a direct approach for the preparation of diverse substituted quinoline derivatives in high yields with wide functional group tolerance. Practically, the protocol can be easily scaled up to gram-scale and was utilized in the concise formal synthesis of a promising herbicide candidate.

Highly Enantioselective Direct Synthesis of Endocyclic Vicinal Diamines through Chiral Ru(diamine)-Catalyzed Hydrogenation of 2,2′-Bisquinoline Derivatives

An asymmetric hydrogenation of 2,2′-bisquinoline and bisquinoxaline derivatives, catalyzed by chiral cationic ruthenium diamine complexes, was developed. A broad range of chiral endocyclic vicinal diamines were obtained in high yields with excellent diastereo- and enantioselectivity (up to 93:7 dl/meso and >99 % ee). These chiral diamines could be easily transformed into a new class of chiral N-heterocyclic carbenes (NHCs), which are important but difficult to access.

Selectivity in the Hydrogenation of 6- and 8-Substituted-quinolines

Quinoline (1) and the 6- or 8-substituted-quinolines (2)-(14) (R = Me, Pri, But, Ph, OMe, OH, CF3, or F) were hydrogenated catalytically on platinum under either weakly basic (solvent MeOH) or strongly acidic (solvent CF3CO2H) conditions.In methanol the only product was the corresponding 1,2,3,4-tetrahydro-compound.In trifluoroacetic acid, compounds hydrogenated in the benzene ring were isolated as major products; both electron-withdrawing and electron-donating substituents at C-6 or C-8 cause (sometimes drastic) reduction in yield.The products were characterized by their 1H and 13C n.m.r. spectra.

Amino-substituted imidazo[1,2-a:3,4-a']diquinolin-15-ium salts compositions and method of use

Amino-substituted imidazo[1,2-a:3,4-a']diquinolin-15-ium salts having the formula I: STR1 wherein R1 is hydrogen, lower alkyl, C4 -C6 cycloalkyl, di(lower alkyl)amino, 1-azetidinyl, 1-pyrrolidinyl, 1-piperidinyl, methyl-1-pyrrolidinyl, methyl-1-piperidinyl, 4-morpholinyl or 2,2-dimethylhydrazino; R2 is hydrogen, lower alkyl, lower alkylamino, di(lower alkyl)amino, C4 -C6 cycloalkylamino, lower alkoxy(lower alkyl)amino, 1-azetidinyl, 1-pyrrolidinyl, 1-piperidinyl, methyl-1-pyrrolidinyl, methyl-1-piperidinyl, hexahydro-1H-azepin-1-yl, 4-morpholinyl, benzylamino, N-methylbenzylamino or 2-phenylethylamino; R3 is hydrogen or methyl; X is an anion; with the proviso that at least one of R1 and R2 is other than hydrogen, lower alkyl or C4 -C6 cycloalkyl; and with the further proviso that when R2 is dimethylamino, at least one of R1 and R3 is other than hydrogen, and intermediates used in the preparation thereof are disclosed. The compounds of the invention are prepared by amination of the corresponding chloro or fluoro-substituted imidazo [1,2-a:3,4-a']diquinolin-15-ium salts; either the halo substituted intermediates or the amino substituted salts may be further treated, typically using ion exchange techniques to obtain a variety of physiologically acceptable amino-substituted [1,2-a:3,4-a']diquinolin-15-ium salts which exhibit antifungal activity.