681465-87-2

Upstream product

• 75-30-9 2-iodo-propane 
• 157942-12-6 methyl 3-hydroxy-4-iodobenzoate 
• 63435-16-5 3-hydroxy-4-aminobenzoic acid methyl ester 
• 681465-85-0 4-amino-3-isopropoxybenzoic acid methyl ester 

Downstream Products

• 681466-00-2 (S)-2-{4-[isobutyl-((S)-1-methoxycarbonylethyl)carbamoyl]-2-isopropoxybenzoylamino}-4-methylpentanoic acid methyl ester 
• 681465-54-3 (S)-2-(4-diisopropylcarbamoyl-2-isopropoxybenzoylamino)-4-methylpentanoic acid methyl ester 
• 681465-98-5 N-isobutyl-2-isopropoxy-N-(1-methoxycarbonyl-ethyl)-terephthalamic acid 
• 681465-96-3 (S)-2-[Isobutyl-(3-isopropoxy-4-vinyl-benzoyl)-amino]-propionic acid methyl ester 
• 681465-93-0 2-isopropoxy-N,N-diisopropylterephthalamic acid 
• 681465-91-8 3-isopropoxy-N,N-diisopropyl-4-vinylbenzamide 
• 852065-43-1 4-formyl-3-isopropoxy-N,N-diisopropylbenzamide 
• 852065-42-0 3-isopropoxy-4-vinylbenzoic acid 
• 681465-89-4 3-isopropoxy-4-vinylbenzoic acid methyl ester 

Relevant academic research and scientific papers

Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-xL protein

A group of novel Bcl-xL/Bak antagonists, based on a terephthalamide scaffold, were designed to mimic the α-helical region of the Bak peptide. Good in vitro inhibition potencies in disrupting the Bak/Bcl-xL complex have been observed (terephthalamide 4, K

Visible light-induced radical addition/annulation to construct phenylsulfonyl-functionalized dihydrobenzofurans involving an intramolecular 1,5-hydrogen atom transfer process

A visible light-induced radical cascade reaction of 2-alkynylarylethers with sodium sulfinates was established for the synthesis of sulfonyl-functionalized dihydrobenzofurans, and an intramolecular 1,5-hydrogen atom transfer was involved in this transformation. This process provided an efficient and convenient C-C formation protocol for the construction of a dihydrobenzofuran ring. Various substituents on 2-alkynylarylethers and sodium sulfinates were tolerated in the reaction, and the corresponding products were obtained in moderate to good yields.

Terephthalamide peptidomimetic compounds and methods

The present invention relates to compounds and pharmaceutical compositions based upon terephthalamide which are proteomimetic and to methods for inhibiting the interaction of an alpha-helical protein with another protein or binding site. Methods for treat

Terephthalamide derivatives as mimetics of helical peptides: Disruption of the Bcl-xL/Bak interaction

A series of Bcl-xL/Bak antagonists, based on a terephthalamide scaffold, was designed to mimic the α-helical region of the Bak peptide. These molecules showed favorable in vitro activities in disrupting the Bcl-xL/Bak BH3 domain comp