Bioorganic and Medicinal Chemistry Letters p. 1375 - 1379 (2004)
Update date:2022-08-05
Topics:
Yin, Hang
Hamilton, Andrew D.
A group of novel Bcl-xL/Bak antagonists, based on a terephthalamide scaffold, were designed to mimic the α-helical region of the Bak peptide. Good in vitro inhibition potencies in disrupting the Bak/Bcl-xL complex have been observed (terephthalamide 4, K<
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