68157-45-9Relevant academic research and scientific papers
Blue Fluorescence from BF2 Complexes of N,O-Benzamide Ligands: Synthesis, Structure, and Photophysical Properties
Yamaji, Minoru,Kato, Shin-Ichiro,Tomonari, Kazuhiro,Mamiya, Michitaka,Goto, Kenta,Okamoto, Hideki,Nakamura, Yosuke,Tani, Fumito
supporting information, p. 12514 - 12519 (2017/10/24)
Small molecules having intense luminescence properties are required to promote biological and organic material applications. We prepared five types of benzamides having pyridine, pyridazine, pyrazine, and pyrimidine rings and successfully converted them i
An efficient, eco-friendly and sustainable tandem oxidative amidation of alcohols with amines catalyzed by heteropolyanion-based ionic liquids via a bifunctional catalysis process
Fu, Renzhong,Yang, Yang,Feng, Wei,Ge, Qiuxia,Feng, Yan,Zeng, Xiaojun,Chai, Wen,Yi, Jun,Yuan, Rongxin
, p. 8319 - 8326 (2016/12/02)
An efficient, eco-friendly and sustainable method for the tandem oxidative amidation of alcohols with amines has been reported. Using heteropolyanion-based ionic liquids as the catalyst and tert-butyl hydroperoxide as the oxidant, this amidation reaction is operationally straightforward and provides a series of primary, secondary and tertiary amides derivatives in moderate to good yields. Solvent-free media, microwave-promoted conditions and reusability of catalysts are the main highlights. Further, the proposed bifunctional catalysis mechanistic pathway has been briefly investigated in this report.
Microwave-assisted heteropolyanion-based ionic liquid promoted sustainable protocol to N-heteroaryl amides via N-directing dual catalyzed oxidative amidation of aldehydes
Fu, Renzhong,Yang, Yang,Jin, Weihua,Gu, Hui,Zeng, Xiaojun,Chai, Wen,Ma, Yunsheng,Wang, Quan,Yi, Jun,Yuan, Rongxin
, p. 107699 - 107707 (2016/11/29)
A sustainable procedure for the synthesis of N-heteroaryl amides directly from oxidative amidation of aldehydes catalyzed by heteropolyanion-based ionic liquids under microwave-promoted conditions has been reported. The transformation has proven to tolerate a wide range of aldehydes and amino heterocycles with different functional groups. Moderate to excellent yields, solvent-free media, operational simplicity and reusability of catalysts are the main highlights. Furthermore, the proposed N-directing dual-catalysis mechanistic pathway was briefly investigated in this report.
Discovery and structure-activity relationship studies of N6-benzoyladenine derivatives as novel BRD4 inhibitors
Noguchi-Yachide, Tomomi,Sakai, Taki,Hashimoto, Yuichi,Yamaguchi, Takao
, p. 953 - 959 (2015/03/04)
Bromodomain and extra-terminal domain (BET) proteins are epigenetic readers that bind to acetylated lysines in histones. Among them, BRD4 is a candidate target molecule of therapeutic agents for diverse diseases, including cancer and inflammatory disease.
N,N-carbonyldiimidazole-mediated amide coupling: Significant rate enhancement achieved by acid catalysis with imidazole - HCI
Woodman, Emily K.,Chaffey, Julian G. K.,Hopes, Philip A.,Hose, David R. J.,Gilday, John P.
supporting information; experimental part, p. 106 - 113 (2010/04/22)
Over a series of 10 aromatic amines we show the rate of CDI mediated amidation to be significantly enhanced upon introduction of imidazole·HCI as a proton source for acid catalysis. Our work supports and provides an application for previous investigations into the imidazolium effect, thus increasing the scope of CDI as an amide-coupling reagent with aromatic amines. The influence of the relative pKa of the amines studied on the rate of reaction was also investigated.
