6818-68-4

Upstream product

• 70631-05-9 N-(1-methyl-2-phenylethyl)benzamide 
• 824-47-5 (1-chloropropan-2-yl)benzene 
• 100-47-0 benzonitrile 
• 1123-85-9 (RS)-2-phenyl-1-propanol 
• 698-87-3 3-phenyl-2-propanol 
• 1013-88-3 Benzophenone imine 
• 35466-83-2 allyl methyl carbonate 
• 591-87-7 Allyl acetate 
• 70122-89-3 tert-butyl allyl carbonate 
• 61463-61-4 2-allylbenzonitrile 
• 100-58-3 phenylmagnesium bromide 

Relevant academic research and scientific papers

3,4-dihydroisoquinoline derivatives and composition for use in preventing or treating sepsis

A composition containing 3,4 - dihydroisoquinoline derivatives and 3,4 - dihydroisoquinoline derivative compounds is provided to prevent or treat sepsis. 3,4 -Lysine (specific demethylase), which is a histone demethylated enzyme, has excellent inhibitory

Cp*Co(III)-Catalyzed γ-Selective C-H Allylation/Hydroamination Cascade for the Synthesis of Dihydroisoquinolines

A Cp*Co(III)-catalyzed γ-selective C-H allylation/hydroamination cascade toward the synthesis of 3,4-dihydroisoquinolines (DHIQs) has been successfully developed, starting from NH ketimines and allyl carbonates. Notably, highly efficient and γ-selective C-H allylations were accomplished using γ-substituted allyl reagents, thus overcoming the issues of poor α/γselectivity and low reactivity of previous transition metal-catalyzed C-H allylations. The stereochemistry of allyl carbonates was a crucial factor, and synthesis of the DHIQs was achieved using (Z)-allyl carbonates.

A Method for Bischler-Napieralski-Type Synthesis of 3,4-Dihydroisoquinolines

A new method for the Bischler-Napieralski-type synthesis of 3,4-dihydroisoquinolines was developed by a Tf2O-promoted tandem annulation from phenylethanols and nitriles. Its success was mainly due to the fact that a phenonium ion was formed in the process and practically functioned as a stable and reactive primary phenylethyl carbocation.

Intervention of Phenonium Ion in Ritter Reactions

The transformation of phenylethyl chloride to 3,4-dihydroisoquinolines is shown to proceed via phenonium ion. The evidence comes from a study of dideuterated analogue 4, and the monomethylated and dimethylated compounds 2 and 3.