68230-28-4

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-bromophenyl)-2-(phenylamino)propanenitrile is used as a key intermediate for the synthesis of pharmaceutical drugs due to its ability to be incorporated into complex molecular structures, enhancing the development of new therapeutic agents.
Used in Medicinal Chemistry:
BPNP is utilized as a versatile building block in medicinal chemistry for the design and synthesis of novel compounds with potential therapeutic properties, contributing to drug discovery and innovation.
Used in Organic Synthesis:
2-(4-bromophenyl)-2-(phenylamino)propanenitrile is used as a synthetic intermediate in organic synthesis for creating a wide range of chemical products, including specialty chemicals and advanced materials, due to its reactivity and structural diversity.

Upstream product

• 99-90-1 para-bromoacetophenone 
• 62-53-3 aniline 
• 7677-24-9 trimethylsilyl cyanide 

Relevant academic research and scientific papers

Cuboctahedral [In36(μ-OH)24(NO3)8(Imtb)24]MOF with Atypical Pyramidal Nitrate Ion in SBU: Lewis Acid-Base Assisted Catalysis and Nanomolar Sensing of Picric Acid

A robust and multifunctional cuboctahedral [In36(μ-OH)24(NO3)8(Imtb)24] MOF (In(Imtb)-MOF) with an atypical pyramidal nitrate ion-containing hitherto unknown SBU core [In9(μ-OH)6(NO3)] is reported. The intra- and interlayer nitrate ions adopt pyramidal an

A: D 3h-symmetry hexaazatriphenylene-tris-N-heterocyclic carbene ligand and its coordination to iridium and gold: Preliminary catalytic studies

A new D3h-symmetry tris-N-heterocyclic carbene ligand has been prepared and coordinated to iridium and gold. The ligand contains an electron-poor hexaazatriphenylene core; thus, the resulting tris-NHC ligand is a poor electron donor. The tris-A

Main-chain organometallic microporous polymers bearing triphenylene-tris(N- heterocyclic carbene)-gold species: Catalytic properties

Two triphenylene-based tris(N-heterocyclic carbene)-gold-acetylide main-chain organometallic microporous polymers (MOMPs) were obtained and fully characterized. Both materials show spherical shapes, and their size is highly dependent on the type of acetyl

Eco-friendly synthesis of α-aminonitriles from ketones in PEG-400 medium using potassium Hexacyanoferrate(II) as cyanide source

An efficient method for the synthesis of α-aminonitriles via one-pot three-component condensation of ketones, amines and potassium hexacyanoferrate(II) using benzoyl chloride as a promoter and PEG-400 as a reaction medium was described. This protocol has

Solid-supported gallium triflate: An efficient catalyst for the three-component ketonic strecker reaction

In light of the growing interest in the use of rare earth metal triflates as water-tolerant Lewis acid catalysts, we embarked upon the development of a solid-supported gallium triflate (PS-Ga(OTf)2) derivative as a means of increasing the clean

Sulfated tungstate: A green catalyst for Strecker reaction

A straightforward, mild, efficient, and general method has been developed for the synthesis of α-aminonitriles via Strecker reaction starting from aldehydes or ketones, amines, and trimethylsilyl cyanide in the presence of sulfated tungstate as a heterogeneous mild solid acid catalyst at room temperature and solvent free condition. The developed method has been successfully applied for the synthesis of a wide range of α-aminonitriles with variable functionality.

Tin exchanged zeolite as catalyst for direct synthesis of α-amino nitriles under solvent-free conditions

Sn exchanged HBeta zeolite was prepared and characterized by PXRD, surface area, TPD and TEM analysis. The Sn exchanged zeolite was found to be highly efficient catalyst for the direct synthesis of α-amino nitrile from various ketones and aldehydes with amine and trimethyl silylcyanide (TMSCN) under solvent-free condition. Excellent yield of α-amino nitrile (up to 96%) was achieved within 10-120 min at room temperature. The Sn exchanged HBeta zeolite was recovered and reused several times without the loss of its catalytic performance.

N-HETEROCYCLIC CARBENE-AMIDO PALLADIUM(II) CATALYSTS AND METHOD OF USE THEREOF

A new N-heterocyclic catalyst system which contains N-heterocyclic carbene and amido as ligands, which are strongly bound to a palladium metal. Another heteroatom functionality can be used as a third ligand L. The NHC-amidate ligand system is unique in structure, and shows excellent reactivities in a number of chemical reactions. The chemical reactions include carbon-carbon and carbon-heteroatom (oxygen and nitrogen) bond formations, and oxidation reactions of saturated carbon chemicals via C—H activation.

Organometallic hollow spheres bearing bis(N-Heterocyclic carbene)-palladium species: Catalytic application in three-component Strecker reactions

Hollow-sphere catalysts were prepared by means of 3D network formation between a tetraimidazolium building block and palladium acetate. The bis(N-heterocyclic carbene)-palladium species that were concomitantly formed during growth of the hollow spheres sh

Synthesis of α-amino nitriles from carbonyl compounds, amines, and trimethylsilyl cyanide: comparison between catalyst-free conditions and the presence of tin ion-exchanged montmorillonite

In the absence of catalysts, the three-component, one-pot synthesis of α-amino nitriles proceeded using various aldehydes and ketones together with amines and trimethylsilyl cyanide (TMSCN) in high yields under neat conditions at room temperature. The addition order of the reagents had a significant influence on the yields of the desired α-amino nitriles. In contrast, when tin ion-exchanged montmorillonite (Sn-Mont), prepared by the ion-exchange of sodium, montmorillonite (Na-Mont) with a tin tetrachloride solution, was used as a catalyst, the reaction rates significantly increased compared with those without catalysts, and the range of the applicable carbonyl compounds was also extended: structurally diverse aromatic, aliphatic and heteroatom-containing carbonyl compounds, including sterically hindered ketones as well as aliphatic and aromatic amines, were converted into the desired α-amino nitriles in good to excellent yields with short reaction times under mild conditions. Sn-Mont showed a better catalytic activity than proton or other metal ion-exchanged montmorillonites, supported SnO2 catalysts and the previously reported homogeneous or heterogeneous catalysts. The recovered catalyst was reused several times without loss of catalytic performance. Along with the expansion of the interlayer space of Sn-Mont, the strong Bransted acid and Lewis acid nature of Sn-Mont derived from protons and SnO2 nanoparticles present in the interlayers of Sn-Mont likely played important and cooperative roles in the high catalytic activity.