68253-30-5Relevant academic research and scientific papers
Electro-oxidative C(sp2)-H/O-H cross-dehydrogenative coupling of phenols and tertiary anilines for diaryl ether formation
Tang, Hongyang,Smolders, Simon,Li, Yun,De Vos, Dirk,Vercammen, Jannick
, p. 3925 - 3930 (2021/06/18)
The formation of diaryl ethers is generally achievedviatransition metal catalyzed etherification reactions (Ullmann, Chan-Lam, Buchwald-Hartwig) with prefunctionalized aryl halide substrates at elevated temperatures. Herein, we report a protocol for electrochemical C(sp2)-H/O-H cross-dehydrogenative coupling of phenols and tertiary anilines to synthesize diaryl ethers. The C(sp2) H/O-H coupling product can be obtained under metal- and oxidant-free conditions at room temperature in moderate to excellent yield (up to 83% yield) with high regioselectivity (>99% forpara-substitution) and with a broad substrate scope (22 examples).
