31465-35-7

Usage

Uses

Used in Pharmaceutical Industry:
4-(4-BROMOPHENOXY)ANILINE is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new medications and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 4-(4-BROMOPHENOXY)ANILINE is employed as an intermediate in the production of agrochemicals, aiding in the creation of pesticides and other agricultural products to enhance crop protection and yield.
Used in Organic Compounds Synthesis:
4-(4-BROMOPHENOXY)ANILINE is used as a key intermediate in the synthesis of various organic compounds, playing a crucial role in the development of new chemical entities and materials.
Used as a Dye Intermediate:
4-(4-BROMOPHENOXY)ANILINE is utilized as a dye intermediate, contributing to the production of dyes used in various industries, including textiles, plastics, and printing inks.
Used in Polymer Manufacturing:
4-(4-BROMOPHENOXY)ANILINE is employed in the manufacturing of polymers, where it serves as a building block for the development of new polymeric materials with specific properties and applications.
Used in Organic Product Manufacturing:
4-(4-BROMOPHENOXY)ANILINE is also used in the production of other organic products, highlighting its versatility and importance in the chemical industry for creating a wide range of products.

InChI:InChI=1/C12H10BrNO/c13-9-1-5-11(6-2-9)15-12-7-3-10(14)4-8-12/h1-8H,14H2

Upstream product

• 21969-04-0 1-(4-nitrophenoxy)-4-bromobenzene 
• 100-00-5 4-chlorobenzonitrile 
• 106-41-2 4-bromo-phenol 
• 101-55-3 4-Bromodiphenyl ether 
• 620-88-2 4-nitrophenyl phenyl ether 
• 101-84-8 diphenylether 

Downstream Products

• 36160-96-0 chloro-acetic acid-[4-(4-bromo-phenoxy)-anilide] 
• 108955-87-9 [4-(4-bromo-phenoxy)-phenyl]-guanidine 
• 2050-47-7 4,4'-dibromodiphenyl ether 
• 30427-95-3 1-bromo-4-(4-chlorophenoxy)benzene 
• 220025-13-8 1-bromo-4-(4-iodophenoxy)benzene 
• 876496-63-8 N-[4-(4-bromophenoxy)phenyl]acetamide 
• 68253-30-5 4-Dimethylamino-4'-brom-diphenylether 
• 13320-48-4 4-hydroxy-4'-bromodiphenyl ether 

Relevant academic research and scientific papers

C-H Amination of Arenes with Hydroxylamine

This Letter describes the development of a TiIII-mediated reaction for the C-H amination of arenes with hydroxylamine. This reaction is applied to a variety of electron-rich (hetero)arene substrates, including a series of natural products and pharmaceuticals. It offers the advantages of mild conditions (room temperature), fast reaction rates (30 min), compatibility with ambient moisture and air, scalability, and the use of inexpensive commercial reagents.

Quinoline derivative as well as preparation method and application thereof (by machine translation)

The invention provides a quinoline derivative and a composition containing the same. The invention also provides a method for preparing the derivative and application of the derivative and the composition to kill pests. (by machine translation)

Synthesis, SAR and molecular docking study of novel non-β-lactam inhibitors of TEM type β-lactamase

The novel classes of acylated phenoxyanilide and thiourea compounds were investigated for their ability to inhibit TEM type β-lactamase enzyme. Two compounds 4g and 5c reveal the inhibition potency in micromolar range and show their action by non-covalent binding in the vicinity of the TEM-171 active site. The structure activity relationship around carbon chain length and different substituents in ortho- and para-positions of acylated phenoxyanilide as well as molecular modelling study has been performed.

Synthesis and biological evaluation of pentanedioic acid derivatives as farnesyltransferase inhibitors

Structure-based virtual screening of a commercial library identified pentanedioic acid derivatives (6 and 13b) as a kind of novel scaffold farnesyltransferase inhibitors (FTIs). Chemical modifications of the lead compounds, biological assays and analysis of the structure-activity relationships (SAR) were conducted to discover more potent FTIs. Some of them displayed excellent inhibition against FTase, and among them, the most active compound 13n with an IC50 value of 0.0029 μM and SAR analysis might be helpful to the discovery of more potent FTIs. This journal is

Discovery of 1,2,4-triazole-1,3-disulfonamides as dual inhibitors of mitochondrial complex II and complex III

Respiratory chain succinate-ubiquinone oxidoreductase (SQR or complex II) and ubihydroquinone-cytochrome (cyt) c oxidoreductase (cyt bc1 or complex III) have been demonstrated as the promising targets of numerous antibiotics and fungicides. As a continuation of our research work on the development of new fungicides, a series of 1,2,4-triazole-1,3-disulfonamide derivatives with dual functions targeting both SQR and cyt bc1 were designed and synthesized by coupling diverse diphenyl ether moieties with triazolesulfonamide units. These newly synthesized compounds were characterized by elemental analyses, 1H NMR and ESI-MS spectrometry. The in vitro assay indicated that most of the synthesized compounds displayed good inhibition against porcine succinate-cytochrome reductase (SCR) with IC50 values ranging from 3.2 to 81.8 μM, revealing much higher activity than that of the commercial control amisulbrom whose IC50 value is 93.0 μM. Further evaluation against the respective SQR and cyt bc1 indicated that most compounds exhibited SQR-inhibiting activity as well as cyt bc1-inhibiting activity, but the inhibition potency against SQR is much higher than that against cyt bc1, showing that the SCR inhibition might be contributed greatly by the SQR inhibition. The further antibacterial evaluation against Xanthomonas oryzae pv. oryzae revealed that four compounds showed excellent potency at the concentration of 20 μg mL-1. In particular, compounds 6h and 6j exhibited much better antibacterial activity than the commercial control bismerthiazol in terms of their EC50. Impressively, 6j has an EC90 of 33.62 μg mL-1, more than 10-fold higher than that of bismerthiazol.