68256-23-5

Upstream product

• 68255-77-6 2-methoxy-4-chloro-5-nitrobenzoic acid 
• 68255-78-7 N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-4-chloro-5-nitrobenzamide 
• 90763-47-6 4-Chloro-2-methoxy-5-nitro-benzoyl chloride 
• 26116-12-1 1-ethyl-2-pyrrolidinemethanamine 

Downstream Products

• 68256-25-7 N-(1-ethyl-2-pyrrolidinylmethyl)-2-methoxy-4-chloro-5-aminosulfonamidobenzamide 

Relevant academic research and scientific papers

Synthesis and Neuroleptic Activity of N--2-methoxy-5-sulfonamidobenzamides

A series of some novel N-benzamides involving replacement of the sulfamoyl group in sulpiride with a sulfonamido group was synthesized and tested for dopamine receptor blockade.In comparison with sulpiride, several compounds were considerably more potent than sulpiride as dopamine receptor blockers.The structure-activity relationships are discussed.

Meta-sulfonamido-benzamides

Meta-sulfonamido-benzamide derivatives of the formula: STR1 [wherein R is a hydrogen atom or a lower alkyl, cyano, or lower alkanesulfonyl group; R1 is a lower alkyl, phenyl, amino, lower alkylamino, di(lower)alkylamino, or C4 -C5 alkyleneamino group; R2 is a hydrogen or halogen atom or a lower alkyl, di(lower)alkylamino, or lower alkoxy group; R3 is a hydrogen atom or a methyl or methoxy group; R4 is a hydrogen or halogen atom; R5 is a lower alkyl, lower alkenyl, C3 -C6 cycloalkyl, benzyl, or halogenobenzyl group; and n is 1 or zero] or their acid addition salts, showing pharmacological activity such as anti-emetic or psychotropic activity, are provided via several routes.