68259-66-5Relevant articles and documents
Synthesis of 1,2,5-thiadiazole-3(2H)-thiones and 1,2,5-thiadiazol-3(2H)-ones from 1,2,3-dithiazoles
Konstantinova, Lidia S.,Bol'shakov, Oleg A.,Obruchnikova, Natalia V.,Golova, Svetlana P.,Nelyubina, Yulia V.,Lyssenko, Konstantin A.,Rakitin, Oleg A.
, p. 84 - 86 (2009)
5H-1,2,3-Dithiazole-5-thiones and 5H-1,2,3-dithiazol-5-ones undergo a new transformation into 1,2,5-thiadiazole-3(2H)-thiones and 1,2,5-thiadiazol-3(2H)-ones, respectively, upon treatment with primary amines; the structure of thiadiazolethione was confirm
Selective amidation by a photocatalyzed umpolung reaction
Ghosh, Debasish,Nandi, Rajesh,Khamarui, Saikat,Ghosh, Sukla,Maiti, Dilip K.
supporting information, p. 3883 - 3886 (2019/05/02)
A metal-catalyzed organic transformation merged with another organophotocatalyst has been developed under mild conditions for production of α-ketoamides. CuI-catalyzed highly selective and rapid COCH2-amidation in the presence of electrophilic CαO bonds, which is synchronized by an eosin Y (EY)-photocatalyst, furnishes a wide range of labile α-ketoamides, unsymmetrical oxalamides and chiral analogues on the treatment of 1,3-dicarbonyls with amines, PhIO and LED light at room temperature. The current strategy opens up a new avenue to making photocatalysis a common synthetic tool for large-scale production in academia and industry.
HETEROCYCLIC MODULATORS OF THE GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-κB ACTIVITY AND USE THEREOF
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Page/Page column 69-70, (2008/06/13)
Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of Formula (I) or stereoisomers or prodrugs or solvates or pharmaceutically acceptable salts thereof, wherein A, B, J, K, Z, R, Ra, Rb, Rc, and Rd, are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.