6826-96-6

Usage

Uses

Used in Pharmaceutical Industry:
4-amino-2H-pyrazolo[3,4-d]pyrimidine-3-carbonitrile is used as a pharmaceutical candidate for the development of antitumor and anticancer drugs. It targets specific enzymes and pathways that contribute to cancer cell growth and proliferation, offering a potential therapeutic approach to combat cancer.
Used in Organic Synthesis:
4-amino-2H-pyrazolo[3,4-d]pyrimidine-3-carbonitrile is used as a reagent in organic synthesis. Its unique structure and properties make it a valuable component in the creation of other biologically active compounds, contributing to the advancement of chemical research and development.
Used in Chemical Industry:
4-amino-2H-pyrazolo[3,4-d]pyrimidine-3-carbonitrile serves as a building block for the synthesis of other complex molecules with potential applications in various fields. Its versatility and chemical properties make it an interesting candidate for further exploration and utilization in the chemical industry.

Upstream product

• 54385-49-8 5-amino-1H-pyrazole-3,4-dicarbonitrile 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 122949-64-8 4-amino-3-cyano-1-<(2-acetoxyethoxy)methyl>pyrazolo<3,4-d>pyrimidine 
• 55559-48-3 4-acetamido-3-cyanopyrazolo<3,4-d>pyrimidine 
• 1613396-30-7 4-amino-1-[1-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]-2-oxo-pyrrolidin-3-yl]pyrazolo[3,4-d]pyrimidine-3-carbonitrile 
• 122949-65-9 methyl 4-amino-1-<(2-hydroxyethoxy)methyl>pyrazolo<3,4-d>pyrimidine-3-formimidate 
• 122949-66-0 4-amino-1-<(2-hydroxyethoxy)methyl>pyrazolo<3,4-d>pyrimidine-3-thiocarboxamide 
• 122949-67-1 4-amino-1-<(2-hydroxyethoxy)methyl>pyrazolo<3,4-d>pyrimidine-3-carboxamide 
• 122949-68-2 4-amino-3-cyano-1-<(2-hydroxyethoxy)methyl>pyrazolo<3,4-d>pyrimidine 

Relevant academic research and scientific papers

ATG7 INHIBITORS AND THE USES THEREOF

Disclosed are chemical entities which are compounds of formula (I) : or a pharmaceutically acceptable salt thereof, wherein R1, R2, and Ra have the values described herein. Chemical entities according to the disclosure can be useful as inhibitors of ATG7. Further provided are pharmaceutical compositions comprising a chemical entity of the disclosure and methods of using the compositions in the treatment of cancer.

4-amino-3-(imidazolylmethyl)-Pyrazolopyridine [3, 4-D] pyrimidinecarboxylic

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are 4-amino-3-imidazoyl-pyrazolo[3,4-d]pyrimidine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.

REACTION OF 4-CYANO-5-AMINOPYRAZOLE AND 3,4-DICYANO-5-AMINOPYRAZOLE WITH DIMETHYLFORMAMIDE DIETHYLACETAL

The condensation of 4-cyano-5-aminopyrazole or 3,4-dicyano-5-aminopyrazole with dimethylformamide diethylacetal was studied.It was shown that, in addition to the formation of dimethylaminomethyleneamino derivatives, alkylation of the pyrazole ring occurs under severe conditions without a solvent.Only the corresponding formamidino derivatives are formed when the same reactions are carried out in methanol under milder conditions.The site of addition of an ethyl group to the pyrazole ring in the N-alkyl derivatives obtained was established by 13C NMR and PMR spectroscopy.The possibility of the synthesis of 4-amino- or 4-methylmercaptopyrazolopyrimidines by cyclization of the ortho position was demonstrated for the first time.