6826-96-6Relevant articles and documents
ATG7 INHIBITORS AND THE USES THEREOF
-
Paragraph 00178, (2018/05/27)
Disclosed are chemical entities which are compounds of formula (I) : or a pharmaceutically acceptable salt thereof, wherein R1, R2, and Ra have the values described herein. Chemical entities according to the disclosure can be useful as inhibitors of ATG7. Further provided are pharmaceutical compositions comprising a chemical entity of the disclosure and methods of using the compositions in the treatment of cancer.
REACTION OF 4-CYANO-5-AMINOPYRAZOLE AND 3,4-DICYANO-5-AMINOPYRAZOLE WITH DIMETHYLFORMAMIDE DIETHYLACETAL
Bulychev, Yu. N.,Korbukh, I. A.,Preobrazhenskaya, M. N.,Chernyshov, A. I.,Esipov, S. E.
, p. 215 - 221 (2007/10/02)
The condensation of 4-cyano-5-aminopyrazole or 3,4-dicyano-5-aminopyrazole with dimethylformamide diethylacetal was studied.It was shown that, in addition to the formation of dimethylaminomethyleneamino derivatives, alkylation of the pyrazole ring occurs under severe conditions without a solvent.Only the corresponding formamidino derivatives are formed when the same reactions are carried out in methanol under milder conditions.The site of addition of an ethyl group to the pyrazole ring in the N-alkyl derivatives obtained was established by 13C NMR and PMR spectroscopy.The possibility of the synthesis of 4-amino- or 4-methylmercaptopyrazolopyrimidines by cyclization of the ortho position was demonstrated for the first time.