682756-48-5

Upstream product

• 682756-44-1 4-iodo-1-[(4-methoxyphenyl)methoxy]benzene 
• 824-94-2 p-methoxybenzyl chloride 
• 540-38-5 p-Iodophenol 
• 682756-46-3 3-{4-[(4-methoxyphenyl)methoxy]phenyl}prop-2-yn-1-ol 

Downstream Products

• 682756-52-1 (1E,3E,5E)-1-{4-[(4-methoxyphenyl)methoxy]phenyl}-6-phenylhexa-1,3,5-triene 
• 682756-54-3 (1E,3E,5E)-1-(4-hydroxyphenyl)-6-phenyl-1,3,5-hexatriene 

Relevant academic research and scientific papers

Phosphorylated 1,6-diphenyl-1,3,5-hexatriene

A lipophilic dye consisting of a (1E,3E,5E)-1,6-diphenyl-1,3,5-hexatriene (DPH) fluorophore attached to a phosphate diester was prepared, and its fluorescence behavior in different solvent systems and in a liposomal membrane bilayer was examined. The key step in the synthesis of the functionalized end of the dye is a Sonogashira coupling of protected iodophenol with propargyl alcohol; the remaining phenyl ring and double bonds of the all-trans polyene core arise from a Wittig reaction with trans-cinnamaldehyde. Like DPH itself, the emission intensity of its phosphorylated derivative is quenched in polar media.