68291-93-0

Usage

Uses

Used in Fragrance and Flavor Industry:
(2H-1,3-benzodioxol-5-ylmethyl)(propyl)amine is used as a key ingredient in the creation of fragrances and flavors due to its appealing scent, enhancing the sensory experience of various consumer products.
Used in Pharmaceutical Synthesis:
Although its use in food and consumer products is restricted due to safety concerns, (2H-1,3-benzodioxol-5-ylmethyl)(propyl)amine, or safrole, serves as a precursor in the synthesis of certain pharmaceuticals, including the recreational drug MDMA (ecstasy). Its role in chemical synthesis is significant for the production of specific compounds.
Used in Historical Flavoring:
Historically, safrole has been used as a flavoring agent in beverages such as root beers and sassafras tea, providing a unique taste profile. However, due to its potential carcinogenic and toxic effects, its use in these applications has been significantly reduced or eliminated in many countries.

Upstream product

• 214783-17-2 5-(azidomethyl)benzo[d][1,3]dioxole 
• 927-77-5 n-propylmagnesium bromide 
• 107-10-8 propylamine 
• 120-57-0 piperonal 
• 71-23-8 propan-1-ol 
• 2620-50-0 1,3-benzodioxol-5-ylmethyl amine 

Relevant academic research and scientific papers

ORGANIC COMPOUNDS

This disclosure relates to taste modifiers of formula (I) wherein, n is 1, 2 or 3; R1 is selected from C1-C5 alkyl, C1-C5 hydroxyalkyl, C1-C5 dihydroxyalkyl and —CHYCOOH wherein

Iridium-catalysed amine alkylation with alcohols in water

Amines have been directly alkylated with alcohols using 1 mol% [Cp*IrI2]2 catalyst in water in the absence of base or other additives. The Royal Society of Chemistry 2010.

Preparation of benzolactams by Pd(OAC)2-catalyzed direct aromatic carbonylation

We developed a new method for Pd(II)-catalyzed direct aromatic carbonylation in a phosphine-free catalytic system using Pd(OAc)2 and Cu(OAc)2 in an atmosphere of CO gas containing air. The carbonylation proceeded with ortho-palladation, inducing a remarkable site selectivity to afford a variety of five- or six-membered benzolactams from secondary ω-arylalkylamines, such as N-alkylbenzylamines or N-alkylphenethylamines. Copyright

A novel and efficient approach to mono-N-alkyl anilines via addition of Grignard reagents to aryl azides

Mono-N-alkyl anilines were obtained in high yields within a short reaction time when various aromatic azides were reacted with alkyl magnesium halides at room temperature.