68299-97-8

Basic information

• Product Name: {6-Fluoro-3-[1-(4-methanesulfinyl-phenyl)-meth-(E)-ylidene]-2-methyl-3H-inden-1-yl}-acetic acid ethyl ester
• Synonyms: {6-Fluoro-3-[1-(4-methanesulfinyl-phenyl)-meth-(E)-ylidene]-2-methyl-3H-inden-1-yl}-acetic acid ethyl ester
• CAS NO: 68299-97-8
• Molecular Weight: 384.471
• Mol File: 68299-97-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {6-Fluoro-3-[1-(4-methanesulfinyl-phenyl)-meth-(E)-ylidene]-2-methyl-3H-inden-1-yl}-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {6-Fluoro-3-[1-(4-methanesulfinyl-phenyl)-meth-(E)-ylidene]-2-methyl-3H-inden-1-yl}-acetic acid ethyl ester(68299-97-8)
• EPA Substance Registry System: {6-Fluoro-3-[1-(4-methanesulfinyl-phenyl)-meth-(E)-ylidene]-2-methyl-3H-inden-1-yl}-acetic acid ethyl ester(68299-97-8)

Safety Data

• Hazardous Substances Data: 68299-97-8(Hazardous Substances Data)

Upstream product

• 38194-50-2 Sulindac 
• 75-04-7 ethylamine 

Relevant articles and documents

Mild Esterification of Carboxylic Acids via Continuous Flow Diazotization of Amines

A new continuous flow protocol for the diazotization of methylamine with 1,3-propanedinitrite in THF is reported. The synthesis of methyl esters was achieved in high yields from a variety of carboxylic acids in 20 min at 90 °C. Additionally, this protocol was extended to other aryl and alkyl amines, namely secondary amines, to produce various substituted esters in high yield using 2-MeTHF as a solvent. The reaction conditions were compatible with many functional groups, namely nitrogen-containing heterocycles, alkynes, alkenes, alcohols, and phenols. Mechanistic investigations reveal that the reaction appears to proceed through a transient diazonium species rather than a diazo intermediate.