68305-29-3

Basic information

• Product Name: 4(1H)-Quinolinone, 3-(4-methoxyphenyl)-
• CAS NO: 68305-29-3
• Molecular Formula: C16H13NO2
• Molecular Weight: 251.285
• Mol File: 68305-29-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4(1H)-Quinolinone, 3-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Quinolinone, 3-(4-methoxyphenyl)-(68305-29-3)
• EPA Substance Registry System: 4(1H)-Quinolinone, 3-(4-methoxyphenyl)-(68305-29-3)

Safety Data

• Hazardous Substances Data: 68305-29-3(Hazardous Substances Data)

Upstream product

• 74599-09-0 (3-(4-methoxyphenyl)oxiran-2-yl)(2-nitrophenyl)methanone 
• 123-11-5 4-methoxy-benzaldehyde 
• 74599-23-8 4-methoxy-2'-nitro-chalcone 
• 62-53-3 aniline 
• 127844-58-0 N-[2-[3-(4-methoxyphenyl)-1-oxo-2-propenyl]phenyl]acetamide 
• 551-93-9 2-aminoacetophenone 
• 136490-89-6 (E)-N-[2-[3-(4-methoxyphenyl)-1-oxo-2-propenyl]phenyl]acetamide 
• 152810-38-3 1-(2'-Acetamidophenyl)-3,3-dimethoxy-2-(4''-methoxyphenyl)propan-1-one 

Downstream Products

• 1053190-01-4 3-(4-hydroxyphenyl)-1H-quinolin-4-one 
• 1053190-05-8 1-ethyl-3-(4-methoxyphenyl)-1H-quinolin-4-one 
• 1053190-03-6 3-(4-methoxyphenyl)-1-methyl-1H-quinolin-4-one 
• 1053190-07-0 3-(4-hydroxyphenyl)-1-methyl-1H-quinolin-4-one 
• 1053190-09-2 1-ethyl-3-(4-hydroxyphenyl)-1H-quinolin-4-one 
• 1621002-90-1 1-propyl-3-(4-hydroxyphenyl)-1H-quinolin-4-one 
• 1621002-85-4 3-(4-methoxyphenyl)-1-propyl-1H-quinolin-4-one 

Relevant articles and documents

Construction of azaisoflavone derivatives by hypervalent iodine reagent-mediated oxidative rearrangement of 2'-nitrochalcone

Fabrication of a synthetic azaisoflavone skeleton from 2'-nitrochalcone was done using oxidative rearrangement with a hypervalent iodine reagent. A key intermediate compound, aminoacetal, was prepared from readily available 2'-nitrochalcone via a PhI(OH)O

Design and synthesis of azaisoflavone analogs as phytoestrogen mimetics

A series of azaisoflavone analogs were designed and synthesized and their transactivation activities and binding affinities for ERα and ERβ were investigated. Among these compounds, 2b and 3a were the most potent with 6.5 and 1.1 μM of EC50, respectively. Molecular modeling study showed putative binding modes of the compound 3a in the active site of ERα and ERβ, which were similar with that of genistein and provided insight of the effect of N-alkyl substitution of azaisoflavones on ERβ activity. Also, a biphasic effect of azaisoflavone analogs on MCF-7 cell growth depending on their concentrations was investigated.

Pharmaceutical compositions comprising 4-quinolones for treating cancers

A non-cytotoxic pharmaceutical composition acting on the proliferation of clonogenic cells in malignant tumors and including an efficient amount of a compound selected among the compounds of formula (I) and (Ia).