68305-29-3

Upstream product

• 74599-09-0 (3-(4-methoxyphenyl)oxiran-2-yl)(2-nitrophenyl)methanone 
• 123-11-5 4-methoxy-benzaldehyde 
• 74599-23-8 4-methoxy-2'-nitro-chalcone 
• 62-53-3 aniline 
• 127844-58-0 N-[2-[3-(4-methoxyphenyl)-1-oxo-2-propenyl]phenyl]acetamide 
• 551-93-9 2-aminoacetophenone 
• 136490-89-6 (E)-N-[2-[3-(4-methoxyphenyl)-1-oxo-2-propenyl]phenyl]acetamide 
• 152810-38-3 1-(2'-Acetamidophenyl)-3,3-dimethoxy-2-(4''-methoxyphenyl)propan-1-one 

Downstream Products

• 1053190-07-0 3-(4-hydroxyphenyl)-1-methyl-1H-quinolin-4-one 
• 1053190-09-2 1-ethyl-3-(4-hydroxyphenyl)-1H-quinolin-4-one 
• 1621002-90-1 1-propyl-3-(4-hydroxyphenyl)-1H-quinolin-4-one 
• 1621002-85-4 3-(4-methoxyphenyl)-1-propyl-1H-quinolin-4-one 
• 1053190-03-6 3-(4-methoxyphenyl)-1-methyl-1H-quinolin-4-one 
• 1053190-05-8 1-ethyl-3-(4-methoxyphenyl)-1H-quinolin-4-one 
• 1053190-01-4 3-(4-hydroxyphenyl)-1H-quinolin-4-one 

Relevant academic research and scientific papers

Construction of azaisoflavone derivatives by hypervalent iodine reagent-mediated oxidative rearrangement of 2'-nitrochalcone

Fabrication of a synthetic azaisoflavone skeleton from 2'-nitrochalcone was done using oxidative rearrangement with a hypervalent iodine reagent. A key intermediate compound, aminoacetal, was prepared from readily available 2'-nitrochalcone via a PhI(OH)O

Efficient construction of 3-arylquinolin-4(1H)-ones via in situ Meinwald rearrangement/intramolecular reductive cyclization of 2′-nitrochalcone epoxides

An efficient method for construction of 3-arylquinolin-4(1H)-ones via in situ Meinwald rearrangement/intramolecular reductive cyclization of 2′-nitrochalcone epoxides has been developed. The practical approach is of excellent functional groups compatibili

Design and synthesis of azaisoflavone analogs as phytoestrogen mimetics

A series of azaisoflavone analogs were designed and synthesized and their transactivation activities and binding affinities for ERα and ERβ were investigated. Among these compounds, 2b and 3a were the most potent with 6.5 and 1.1 μM of EC50, respectively. Molecular modeling study showed putative binding modes of the compound 3a in the active site of ERα and ERβ, which were similar with that of genistein and provided insight of the effect of N-alkyl substitution of azaisoflavones on ERβ activity. Also, a biphasic effect of azaisoflavone analogs on MCF-7 cell growth depending on their concentrations was investigated.

Synthesis of azaisoflavones and their inhibitory activities of NO production in activated microglia

A series of azaisoflavones were synthesized and their biological activities were evaluated for nitric oxide (NO) production and inducible NO synthase (iNOS) expression in BV-2 microglia cell lines. Among these compounds, compound 8d was the most potent with IC50 7.83 μM for inhibition of NO production. Also, compound 8d inhibited expression of iNOS in LPS-induced BV2 cells. This result suggests that compound 8d inhibited the production of NO by suppressing the expression of iNOS.

Pharmaceutical compositions comprising 4-quinolones for treating cancers

A non-cytotoxic pharmaceutical composition acting on the proliferation of clonogenic cells in malignant tumors and including an efficient amount of a compound selected among the compounds of formula (I) and (Ia).

Oxidative Rearrangement of 2'-Acetamidochalcones with Thallium(III) Nitrate: A New Route to 3-Aryl-4(1H)-quinolones

A convenient synthesis of the 3-aryl-4(1H)-quinolones (azaisoflavones) 8 and 10 has been achieved by oxidative rearrangement of the 2'-acetamidochalcones 2 and 4, respectively. Key words: Quinolones; azaisoflavones; thallium(III) nitrate.