6832-96-8

Basic information

• Product Name: Butanamide, 2-ethyl-N-phenyl-
• CAS NO: 6832-96-8
• Molecular Formula: C12H17NO
• Molecular Weight: 191.273
• Mol File: 6832-96-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Butanamide, 2-ethyl-N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanamide, 2-ethyl-N-phenyl-(6832-96-8)
• EPA Substance Registry System: Butanamide, 2-ethyl-N-phenyl-(6832-96-8)

Safety Data

• Hazardous Substances Data: 6832-96-8(Hazardous Substances Data)

Upstream product

• 27166-57-0 2,2-diethyl-N-phenyl-malonamic acid 
• 510-20-3 diethyl malonic acid 
• 587-14-4 N,N'-diphenylsulfamide 
• 15745-94-5 3,3-diethyl-1-phenyl-azetidine-2,4-dione 
• 103-71-9 phenyl isocyanate 
• 97-96-1 2-Ethylbutyraldehyde 
• 103-72-0 phenyl isothiocyanate 
• 41295-23-2 2-ethyl-N-methyl-N-phenylbutanamide 
• 2736-40-5 chlorure d'acide ethyl-2 butyrique 
• 100-61-8 N-methylaniline 
• 622-37-7 Phenyl azide 
• 77-25-8 diethyl diethylmalonate 
• 88-09-5 2-Ethylbutanoic acid 
• 153035-24-6 N-Phenyl-2-(trimethylsilyl)propenamide 

Downstream Products

• 7325-42-0 2-(1-ethyl-propylidene)-3-phenyl-oxazolidine-4,5-dione 
• 171078-31-2 N-(2-ethylbut-1-en-1-ylidene)aniline 
• 6668-36-6 N-(2-ethylbutyl)aniline 

Relevant articles and documents

Preparation method of amide

The invention relates to a preparation method of an amide, wherein, under the action of oxygen, the isothiocyanate and the aldehyde can react to form an amide, and the reaction temperature can be effectively increased only when not less than 110 °C. This process is also suitable for the reaction of isocyanates with aldehydes to produce amides. The preparation method is cheap in raw material, wide in substrate application range and free of metal catalysts in the reaction process. The initiator or other activator is green and economical, and can effectively reduce the cost.

Base-catalyzed synthesis of aryl amides from aryl azides and aldehydes

Aryl amides have been used as important compounds in pharmaceuticals, materials and in molecular catalysis. The methods reported to prepare aryl amides generally require very specific reagents, and the most popular carboxyl-amine coupling reactions demand stoichiometric activators. Herein, we report that aryl azides react with aldehydes under base-catalyzed conditions to yield aryl amides efficiently. Mechanistic investigations support the formation of triazoline intermediates via azide-enolate cycloaddition, which subsequently undergo rearrangement to give amides by either thermal decomposition (20-140 °C) or aqueous acid work-up at room temperature. The strategy does not require nucleophilic anilines and is especially efficient for highly electron-deficient aryl amides, including perfluoroaryl amides, which are otherwise challenging to synthesize.

Hydroalumination of Ketenimines and Subsequent Reactions with Heterocumulenes: Synthesis of Unsaturated Amide Derivatives and 1,3-Diimines

The series of differently substituted ketenimines 1 was hydroluminated using di-iso-butyl aluminum hydride. For the sterically congested ketenimine 1a, preferred hydroalumination of the C=N-bond was proven by X-ray crystallography (compound 5a). In situ treatment of the hydroaluminated ketenimines 5 with various heterocumulenes like carbodiimides, isocycanates, isothiocyanates and ketenimines as electrophiles and subsequent hydrolytic workup resulted in novel enamine derived amide species in case of N-attack (sterically less hindered ketenimines) under formation of a new C-N-bond or in 1,3-diimines by C-C-bond-formation in case of bulky substituents at the ketenimine-nitrogen atom. Furthermore, domino reactions with more than 1 equiv of the electrophile or by subsequent addition of two different electrophiles are possible and lead to polyfunctional amide derivatives of the biuret type which are otherwise not easily accessible.