510-20-3

Usage

Uses

Diethylmalonic acid is used in chemistry as a buffer with a capacity of pH values above 5.8.

InChI:InChI=1/C7H12O4/c1-3-7(4-2,5(8)9)6(10)11/h3-4H2,1-2H3,(H,8,9)(H,10,11)

Upstream product

• 57-44-3 diethylbarbituric acid 
• 1634-72-6 2-ethyl-2-(hydroxymethyl)butanal 
• 75-03-6 ethyl iodide 
• 105-53-3 diethyl malonate 
• 77-25-8 diethyl diethylmalonate 
• 29141-71-7 2,2-Diethyl-malonamide 
• 77-32-7 thiobarbital 
• 7732-18-5 water 
• 52927-25-0 diethylthiomalonuric acid 
• 7697-37-2 nitric acid 
• 39623-07-9 isopropylidene diethylmalonate 
• 33376-32-8 5,5-diethyl-dihydro-pyrimidine-4,6-dione 
• 736-78-7 1-benzoyl-5,5-diethyl-pyrimidine-2,4,6-trione 

Downstream Products

• 27132-23-6 diethylmalonic acid dimethyl ester 
• 77-25-8 diethyl diethylmalonate 
• 6832-96-8 2-ethyl-N-phenylbutanamide 
• 88-09-5 2-Ethylbutanoic acid 
• 15719-64-9 methylammonium carbonate 
• 5456-23-5 2-ethyl-2-bromo-butyric acid 
• 54505-72-5 diethylmalonyl chloride 
• 2274-01-3 N-carbamoyl-2-ethylbutyraldehyde 
• 102172-16-7 diethyl-malonic acid diphenyl ester 
• 84836-32-8 2-Ethyl-1-(4-methoxy-phenyl)-butan-1-one 
• 50390-52-8 2-ethyl-1-(p-tolyl)butan-1-one 
• 2983-38-2 ethyl 2-ethylbutanoate 
• 93504-83-7 2-(ethoxycarbonyl)-2-ethylbutanoic acid 
• 340719-77-9 N-[2-ethyl-2-(pyrrolidine-1-ylcarbonyl)-butanoyl]-4-benzoyl-L-phenylalanine 

Relevant academic research and scientific papers

COMPOUNDS AND USES

The invention relates to novel compounds (I), the use of compounds in eliciting a pro-Th17 immune response and related aspects. Further provided are methods of production of said compounds (I).

Copper(II)-catalyzed enantioselective intramolecular cyclization of N-alkenylureas

The first Cu(II)-catalyzed highly enantioselective intramolecular cyclization of N-alkenylureas was developed for the concise assembly of chiral vicinal diamino bicyclic heterocycles. Facile removal of carbonyl group of the carbamido moiety allowed for ready access to enantioenriched cyclic vicinal diamines.

Phenylalanine derivatives

Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α 4 integrin. They are used as therapeutic agents for various diseases concerning α 4 integrin.

Microwave assisted hydrolysis of Meldrum's acid derivatives and decarboxylation of derived malonic acids

Microwave induced hydrolysis of alkyl Medrum's acids and decarboxylation of derived malonic acids using poly-4-vinylpyridine as a catalyst gives high yields of carboxylic acids in a short time.

Process for preparing alkyl- and arylmalonic acids

Alkyl- and arylmalonic acids of the formula I STR1 where R1 =H, C1 -C12 -alkyl, phenyl, C1 -C4 -alkylphenyl, C2 -C4 -dialkylphenyl, R2 =C1 -C12 -alkyl, phenyl, C1 -C4 -alkylphenyl, C2 -C4 -dialkylphenyl or R1 +R2 =--CH2 --CH2 --, are prepared by alkaline saponification by hydrolyzing the corresponding C1 -C4 -alkyl esters of the malonic acid of formula I, with alkali metal hydroxide dissolved in an aqueous alkali metal salt solution containing salt at 90-100% of saturation, acidifying the hydrolysis product with a mineral acid, removing the precipitated alkali metal salt which forms upon acidification, and extracting the alkyl- and arylmalonic acid formed from the aqueous solution with the aid of an organic solvent.

1,1-Alkanediol dicarboxylate linked antibacterial agents

Useful antibacterial agents in which a penicillin and/or a beta-lactamase inhibitor are linked via 1,1-alkanediol dicarboxylates are of the formula STR1 where A is the residue of certain dicarboxyic acids, R3 is H or (C1 -C3), n is zero or 1 such that when n is zero R is P or B and R1 is the residue of certain esters, H or a salt thereof; and when n is 1, one of R and R1 is P and the other is B, and P is STR2 where R2 is H or certain acyl groups, and B is the residue of a beta-lactamase inhibiting carboxylic acid; a method for their use, pharmaceutical compositions thereof and intermediates useful in their production.

Bis-esters of dicarboxylic acids with amoxicillin and certain hydroxymethylpenicillanate 1,1-dioxides

Antibacterial bis-esters of 1,4-cyclohexanedicarboxylic acids and alkane dicarboxylic acids wherein the ester moieties are derived from different alcohols; one alcohol being hydroxymethylpenicillanate 1,1-dioxide, or the 6-beta-hydroxymethyl or the 6-alpha-aminomethyl derivative thereof; and the other being 6-[D-(2-amino-2-(p-hydroxyphenyl)acetamido)]penicillanic acid (amoxicillin); and pharmaceutically acceptable salts thereof; a method for the use of said esters and their salts, and methods for their preparation.